Abstract
An array of odontogenic lesions manifest in the maxillofacial region with variable presentations. The biological behavior of lesions, such as odontogenic keratocyst (OKC), dentigerous cyst (DC), and ameloblastoma (AM) always invite debate. Glucose transporter 1 (GLUT-1) is proven to be an indicator of metabolic behavior of several benign and malignant neoplasms. The purpose of this study was to evaluate the expression of GLUT-1 in OKC, DC, and AM to understand their metabolic behavior. Immunohistochemical expression of GLUT-1 was evaluated in each of the 15 cases of OKC, DC, and AM. The number of labeled cells, staining intensity, and membrane or cytoplasmic expressions were the parameters assessed and analyzed using chi-square test. All cases showed positive GLUT-1 expression: 86.6% OKC showed more than 50% labeled cells followed by DC (40%) and AM (26.5%); 53.3% OKC showed strong intensity in comparison to AM, which showed weak intensity in 53.3% cases; 86.6% of OKCs showed both membrane and cytoplasmic expression followed by DC (40%) and AM (26.6%), whereas 73.3% of AM showed only membrane expression followed by DC (60%) and OKC (13.3%). Odontogenic keratocyst was found out to be more metabolically active followed by DC and AM.
References
Apr 30, 2002·Oral Oncology·Mervyn Shear
Feb 6, 2003·The British Journal of Nutrition·I Stuart Wood, Paul Trayhurn
Jul 19, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Mitsunobu OtsuruAkihiro Kaneko
Jul 29, 2008·Current Genomics·Feng-Qi Zhao, Aileen F Keating
Sep 4, 2008·Journal of Experimental & Clinical Cancer Research : CR·Paola ParenteGiulio Bigotti
Oct 2, 2008·Oral Diseases·J T SallaR A Mesquita
Nov 5, 2008·Annals of Nuclear Medicine·Choichi HoriuchiTomio Inoue
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Bernard Thorens, Mike Mueckler
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernanda Rocha Rojas AyalaFernando Augusto Soares
Mar 29, 2011·Histopathology·Alexander W EckertUdo Bilkenroth
Aug 3, 2011·Clinics·Kátia C CarvalhoFernando A Soares
May 4, 2012·Head & Neck Oncology·Wan-Qin ShenHong-Tian Yao
Jun 21, 2012·Brazilian Oral Research·Manickam SelvamaniPraveen Shivappa Basandi
Jun 15, 2013·Journal of Investigative and Clinical Dentistry·Nigel R JohnsonMartin D Batstone
Apr 11, 2014·Head and Neck Pathology·Alicia Rumayor PiñaOslei Paes de Almeida
Jul 23, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Alicia RumayorOslei Paes de Almeida
Aug 20, 2014·Journal of Clinical and Experimental Dentistry·Rocío Sánchez-BurgosMiguel Burgueño-García
Sep 16, 2014·Annals of Medical and Health Sciences Research·P SwethaAss Sameera
Nov 5, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Thiago de Santana SantosPaulo Ricardo Saquete Martins-Filho
Dec 6, 2014·Medicina oral, patología oral y cirugía bucal·Beatriz Vera-SireraFrancisco Vera-Sempere
Jun 13, 2015·Journal of Oral Science·Vidya C Angadi, Punnya V Angadi
Jun 21, 2015·International Journal of Surgical Pathology·Asmaa Gaber AbdouDaliah Elsakka
Jun 24, 2015·SpringerPlus·Satoshi SenoKazuro Sugimura
Mar 5, 2016·Journal of Oral Biology and Craniofacial Research·Neha AzadVijay Kumar
Mar 12, 2016·BMC Oral Health·Beatriz Vera-SireraFrancisco Vera-Sempere
Mar 25, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Roseane Carvalho VasconcelosLélia Batista de Souza
Mar 30, 2016·International Journal of Surgical Pathology·Celeste Sánchez-RomeroOslei Paes de Almeida
Dec 3, 2016·Journal of Oral Biology and Craniofacial Research·Myriam A KossMaría E López