Glucose transporter 2 expression is down regulated following P2X7 activation in enterocytes

Journal of Cellular Physiology
Jean-François BourzacFernand-Pierre Gendron

Abstract

With the diabetes epidemic affecting the world population, there is an increasing demand for means to regulate glycemia. Dietary glucose is first absorbed by the intestine before entering the blood stream. Thus, the regulation of glucose absorption by intestinal epithelial cells (IECs) could represent a way to regulate glycemia. Among the molecules involved in glycemia homeostasis, extracellular ATP, a paracrine signaling molecule, was reported to induce insulin secretion from pancreatic β cells by activating P2Y and P2X receptors. In rat's jejunum, P2X7 expression was previously immunolocalized to the apex of villi, where it has been suspected to play a role in apoptosis. However, using an antibody recognizing the receptor extracellular domain and thus most of the P2X7 isoforms, we showed that expression of this receptor is apparent in the top two-thirds of villi. These data suggest a different role for this receptor in IECs. Using the non-cancerous IEC-6 cells and differentiated Caco-2 cells, glucose transport was reduced by more than 30% following P2X7 stimulation. This effect on glucose transport was not due to P2X7-induced cell apoptosis, but rather was the consequence of glucose transporter 2 (Glut2)'s internalization. Th...Continue Reading

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Citations

Jan 15, 2014·Pflügers Archiv : European journal of physiology·Jeroen H F de BaaijJoost G J Hoenderop
Nov 19, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Maude S BilodeauFernand-Pierre Gendron
Oct 2, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Brandon G ShokoplesErnesto L Schiffrin
Oct 12, 2017·Scientific Reports·Guillaume ArguinFernand-Pierre Gendron
Nov 22, 2020·European Journal of Pharmacology·Guilherme Pegas Teixeira, Robson Xavier Faria
Aug 8, 2021·Cells·Izadora Lorrany Alves RabeloClaudiana Lameu

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