Glucose transporters in rat peripheral nerve: paranodal expression of GLUT1 and GLUT3

Metabolism: Clinical and Experimental
P MagnaniF C Brosius

Abstract

Peripheral nerve depends on glucose oxidation to energize the repolarization of excitable axonal membranes following impulse conduction, hence requiring high-energy demands by the axon at the node of Ranvier. To enter the axon at this site, glucose must be transported from the endoneurial space across Schwann cell plasma membranes and the axolemma. Such transport is likely to be mediated by facilitative glucose transporters. Although immunohistochemical studies of peripheral nerves have detected high levels of the transporter GLUT1 in endoneurial capillaries and perineurium, localization of glucose transporters to Schwann cells or peripheral axons in vivo has not been documented. In this study, we demonstrate that the GLUT1 transporter is expressed in the plasma membrane and cytoplasm of myelinating Schwann cells around the nodes of Ranvier and in the Schmidt-Lanterman incisures, making them potential sites of transcellular glucose transport. No GLUT1 was detected in axonal membranes. GLUT3 mRNA was expressed only at low levels, but GLUT3 polypeptide was barely detected by immunocytochemistry or immunoblotting in peripheral nerve from young adult rats. However, in 13-month-old rats, GLUT3 polypeptide was present in myelinated f...Continue Reading

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Citations

Jun 18, 2020·Frontiers in Cellular Neuroscience·Filipa Bouçanova, Roman Chrast
Oct 12, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Aug 29, 2003·Expert Opinion on Investigational Drugs·Anders A F Sima
Dec 21, 2007·Nature Reviews. Neuroscience·David R Tomlinson, Natalie J Gardiner
Feb 10, 2017·Journal of Natural Medicines·Bing XueLian-Qing Sun
Dec 13, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Sep 22, 2007·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Thomas LandegrenJonas K E Persson
May 11, 2012·Journal of the Peripheral Nervous System : JPNS·Lucy M HinderEva L Feldman
Sep 14, 2013·Journal of the Peripheral Nervous System : JPNS·Caleb W GroteDouglas E Wright
Nov 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Atul Rawat, Brett M Morrison

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