Glucose transporters in the kidney in health and disease.

Pflügers Archiv : European journal of physiology
Volker Vallon

Abstract

The kidneys filter large amounts of glucose. To prevent the loss of this valuable fuel, the tubular system of the kidney, particularly the proximal tubule, has been programmed to reabsorb all filtered glucose. The machinery involves the sodium-glucose cotransporters SGLT2 and SGLT1 on the apical membrane and the facilitative glucose transporter GLUT2 on the basolateral membrane. The proximal tubule also generates new glucose, particularly in the post-absorptive phase but also to enhance bicarbonate formation and maintain acid-base balance. The glucose reabsorbed or formed by the proximal tubule is primarily taken up into peritubular capillaries and returned to the systemic circulation or provided as an energy source to further distal tubular segments that take up glucose by basolateral GLUT1. Recent studies provided insights on the coordination of renal glucose reabsorption, formation, and usage. Moreover, a better understanding of renal glucose transport in disease states is emerging. This includes the kidney in diabetes mellitus, when renal glucose retention becomes maladaptive and contributes to hyperglycemia. Furthermore, enhanced glucose reabsorption is coupled to sodium retention through the sodium-glucose cotransporter S...Continue Reading

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Citations

Aug 12, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell, Volker Vallon
Oct 3, 2020·Nature Reviews. Nephrology·Adriana MartonJens Titze
Jun 20, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro Masuda, Daisuke Nagata
Sep 4, 2020·International Journal of Molecular Sciences·Sanaa SharariFaiyaz Ahmad Khan
Sep 8, 2020·American Journal of Physiology. Renal Physiology·Akira OnishiVolker Vallon
Nov 17, 2020·Annual Review of Physiology·Volker Vallon, Subodh Verma
Apr 16, 2021·Kidney International·Asel S ArykbaevaJan H N Lindeman
May 29, 2021·Archives of Physiology and Biochemistry·Chang GuoGuoyue Yuan
May 18, 2021·World Journal of Diabetes·Rajni Sharma, Swasti Tiwari

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Methods Mentioned

BETA
gene knockout
bilateral
biopsies

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