PMID: 9189645Jun 1, 1997Paper

Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus

Clinical and Investigative Medicine. Médecine Clinique Et Experimentale
J L ChiassonP Maheux

Abstract

To characterize the effect of pregnancy on glucose turnover and gluconeogenesis in healthy women and in women with well-controlled insulin-dependent diabetes mellitus (IDDM). Prospective clinical study. Clinical research unit of the Hôtel-Dieu de Montréal hospital. Five healthy pregnant women and 6 pregnant women with IDDM. Glucose turnover and gluconeogenesis in the postabsorptive state at 16 and 32 weeks' gestation and at 24 weeks postpartum were studied with the use of a double stable isotope technique (D[2,3,4,6,6(2)H]-glucose and L[1,2,3(13)C]-alanine). In the women with IDDM, plasma glucose levels were controlled by continuous subcutaneous insulin infusion throughout pregnancy and with a Biostator on the morning of the study. In the women without IDDM, hepatic glucose production was 11.6 (standard error of the mean [SEM] 2.2) mumol/kg per minute at 16 weeks' gestation, 12.5 (SEM 1.8) mumol/kg per minute at 32 weeks' gestation, and 13.2 (SEM 1.9) mumol/kg per minute at 24 weeks postpartum. In the women with IDDM, it was 10.7 (SEM 2.4) mumol/kg per minute, 10.5 (SEM 1.2) mumol/kg per minute and 12.3 (SEM 0.5) mumol/kg per minute at the same respective periods. The difference in levels between the 2 groups was not significan...Continue Reading

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Journal of Cataract and Refractive Surgery
Ioannis HalkiadakisHoward V Gimbel
Journal of Veterinary Internal Medicine
E ZiniC E Reusch
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Xiao-hong XuXiao-wen He
© 2021 Meta ULC. All rights reserved