PMID: 7007950Sep 1, 1980Paper

Glucose turnover, tolerance and insulin response in wethers, ewes and pregnant ewes in the fed and fasted state

The Onderstepoort Journal of Veterinary Research
J G Van Der WaltF J Labuschagne

Abstract

Glucose turnover parameters were obtained in fed and fasted wethers, ewes and pregnant ewes in their 2nd and 3rd trimesters, using a jugular bolus injection of D-glucose-2-3H. Fasting significantly (P less than 0,05) reduced glucose turnover (c. 40%) in both the wether and the non-pregnant ewe. A somewhat larger difference (c. 54%) between the fed and fasted ewes was found in their 3rd trimester of pregnancy due to an increase when fed (c. 29% higher turnover than in the non-pregnant ewe) rather than a decrease when fasted, since there was no statistical difference (P less than 0,1) between glucose turnover values of pregnant or non-pregnant fasted ewes. Glucose tolerance was estimated from an intrajugular glucose load (1 g/kg0,75 body mass) in these 3 groups of sheep under both fed and fasted conditions, and the resulting insulin response was followed for 4 hr after the injection. Fasting reduced the plasma clearance rate of glucose by c. 63% in both the wether and the non-pregnant ewe while the reduction was somewhat smaller (c. 51%) during the 2nd trimester of pregnancy. Only the pregnant ewe group showed a corresponding reduction in the resulting insulin response of 46% which was similar in magnitude to the diminished clear...Continue Reading

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