PMID: 8946385Nov 25, 1996Paper

Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process

Molecular and Biochemical Parasitology
Kiaran KirkJ Kirk

Abstract

The uptake of glucose into human erythrocytes infected with Plasmodium falciparum was investigated using a number of different glucose analogues. In short time-courses with cells suspended in media containing 5 mM glucose, 2-deoxy-D-glucose equilibrated rapidly between the intracellular and extracellular compartments. Its transport into the infected cell was primarily via the host cell (cytochalasin B-sensitive) transporter. 2-Deoxy-D-glucose did permeate the broad-specificity pathway that is induced in infected cells by the intracellular parasite. However, this pathway made little contribution to the total uptake of 2-deoxy-D-glucose under physiological conditions. In parasitised cells incubated with [14C]2-deoxy-D-glucose for prolonged periods the intracellular concentration of radiolabel increased to values higher than that in the external medium; it reached a maximum value three to six times higher than the extracellular concentration before falling back to a concentration similar to that outside the cells. This transient intracellular accumulation of radiolabel was due entirely to the phosphorylation of the [14C]2-deoxy-D-glucose and its consequent trapping within the cell. The specific characteristics of the 2-deoxy-D-glu...Continue Reading

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Citations

Sep 22, 2001·International Journal for Parasitology·S KrishnaC Woodrow
Sep 22, 2001·International Journal for Parasitology·K J Saliba, K Kirk
Nov 19, 2002·International Journal for Parasitology·Sanjeev KrishnaPeter G Kremsner
Jul 14, 1998·Molecular and Biochemical Parasitology·J I PennyS Krishna
Dec 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin BlumeNishith Gupta
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J WoodrowS Krishna
Jul 1, 2010·Biology of the Cell·Valerie Polonais, Dominique Soldati-Favre
Jun 29, 2004·Biochemical and Biophysical Research Communications·Adele M LehaneKiaran Kirk
Apr 28, 2004·International Journal for Parasitology·Henry M StainesJ Clive Ellory
Apr 9, 2005·Molecular Microbiology·Patrick G BrayDavid A Fidock
Dec 12, 2013·The Biochemical Journal·Kiaran Kirk, Adele M Lehane
Sep 7, 2012·The Biochemical Journal·Margery A BarrandStephen B Hladky
Sep 23, 2003·Expert Opinion on Therapeutic Targets·T JoëtS Krishna
Sep 9, 2004·The Journal of Veterinary Medical Science·Takashi OhmoriKenichiro Ono
May 19, 2007·Molecular and Biochemical Parasitology·Ping WangJohn E Hyde
Sep 21, 2010·Molecular and Biochemical Parasitology·Kellen L Olszewski, Manuel Llinás
Jul 13, 2016·Cellular Microbiology·Patrícia MeirelesMiguel Prudêncio
Mar 30, 2001·The Journal of Biological Chemistry·K J Saliba, K Kirk
Mar 6, 1999·The Journal of Biological Chemistry·C J WoodrowS Krishna
May 15, 2001·American Journal of Physiology. Cell Physiology·H M StainesK Kirk
Jun 4, 2002·The Journal of Biological Chemistry·Suzanne K ManningSanjeev Krishna
Nov 2, 2015·Malaria Journal·Marta CovaLuis Izquierdo
Jan 31, 2020·Nature·Abdul Aziz QureshiDavid Drew
Aug 28, 2020·Malaria Journal·Sarah El Chamy MalufAdriana Karaoglanovic Carmona
Mar 29, 2001·Physiological Reviews·K Kirk
Aug 21, 2008·The Journal of Pharmacology and Experimental Therapeutics·Donelly A van SchalkwykKevin J Saliba
Jun 7, 2020·Parasites & Vectors·Mengfei Wang, Jingwen Wang
Nov 9, 2019·Biological Reviews of the Cambridge Philosophical Society·Rowena E Martin
Feb 2, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Felipe Finger BanfiBruno Antonio Marinho Sanchez

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