PMID: 2110394Feb 1, 1990Paper

Glucosinolates toxicity in growing rats: interactions with the hepatic detoxification system

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
L Nugon-BaudonP Raibaud

Abstract

1. Glucosinolate-rich diet (RM) in growing rats increased liver (a), kidneys (b), and thyroid (c) weights and depleted feed intake (d), growth curve (e) and T4 and T3 plasma levels (f). 2. Oral administration of phenobarbital enhanced the toxic effect of RM on (b), (d) and (e) and did not modify the toxic effect of RM on (a), (c) and (f). 3. RM had a depleting effect on hepatic microsomal P-450 specific activity. 4. RM had an enhancing effect on hepatic glutathione S-transferase and UDP-glucuronyltransferase specific activities. 5. These results indicate that some glucosinolate derivatives released by gut microflora metabolism are further metabolized by the hepatic detoxification system, and that they could play the role of co-toxic or co-detoxic molecules.

Citations

Aug 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M Kore, M A Wallig
Aug 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N RolandL Nugon-Baudon
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D V MauriceJ F Rhoades
Sep 1, 1994·The Journal of Applied Bacteriology·K H Yeoman, C Edwards
Feb 28, 1997·Chemico-biological Interactions·D T VerhoevenG van Poppel
Sep 28, 2014·Applied and Environmental Microbiology·Julie A L KieboomsLynn Vanhaecke
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Sonia PiacenteCosimo Pizza

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