Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG.

Journal of Natural Medicines
Motofumi KumazoeHirofumi Tachibana

Abstract

Animal and clinical studies have revealed that (-)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.

References

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Oct 6, 2019·Biochemical and Biophysical Research Communications·Jaehoon BaeHirofumi Tachibana
Mar 17, 2020·Biochemical and Biophysical Research Communications·Motofumi KumazoeHirofumi Tachibana

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