Glucosylated N-acetyllactosamine O-antigen chain in the lipopolysaccharide from Helicobacter pylori strain UA861

Glycobiology
M A MonteiroM B Perry

Abstract

The O-antigen chain from the lipopolysaccharide of Helicobacter pylori strain UA861 was determined to be composed of an elongated type 2 N -acetyllactosamine backbone, -[-->3)-beta-D-Gal-(1-->4)-beta-D-GlcNAc-(1-]n-->, with approximately half of the GlcNAc units carrying a terminal alpha-d-Glc residue at the O -6 position. The O-chain of H.pylori UA861 was terminated by a N -acetyllactosamine [beta-D-Gal-(1-->4)-beta-D-GlcNAc] (LacNAc) epitope and did not express terminal Lewis X or Lewis Y blood-group determinants as previously found in other H.pylori strains. The absence of terminal Lewis X and Lewis Y blood-group epitopes and the replacement of Fuc by Glc as a side chain in the O-chain of H.pylori UA861 represents yet another type of lipopolysaccharide structure from H.pylori species. These structural differences in H.pylori lipopolysaccharide molecules carry implications with regard to possible different pathogenic events between strains and respective hosts.

References

Jan 1, 1987·American Journal of Clinical Pathology·D E TaylorL D Jewell
Nov 1, 1967·Analytical Chemistry·R K SkogerboeG H Morrison
Dec 1, 1995·Infection and Immunity·R Sherburne, D E Taylor
Oct 1, 1995·Glycobiology·N W ChanM M Palcic
Sep 1, 1996·Journal of Clinical Microbiology·I M Simoons-SmitJ de Graaff

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Citations

Oct 27, 2010·Gut Microbes·Dawn A Israel, Richard M Peek
Sep 11, 2019·International Journal of Molecular Sciences·Marguerite Clyne, Felicity E B May

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