PMID: 22574443May 12, 2012Paper

Glucosylated sesquiterpene alcohols from Fraxinus griffithii

Natural Product Communications
Rene Angelo MacahigTakakazu Shinzato

Abstract

Phytochemical investigation of the leaves of Fraxinus griffithii has led to the isolation of two new glucosylated acyclic sesquiterpene alcohols, griffithosides D (1) and E (2), along with iridoid and secoiridoid glycosides. The molecular structures of these compounds were elucidated using NMR, MS and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity and cytotoxicity against A549 human lung adenocarcinoma cells and Leishmania major parasites.

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