PMID: 11332534May 3, 2001Paper

Glucosyltransferase inactivation reduces dental caries

Journal of Dental Research
K S Devulapalle, G Mooser

Abstract

Dental caries has been an intractable disease in spite of intense dental research. The metabolic acids produced by mutans streptococci demineralize the tooth surface and lead to dental caries. The enzyme glucosyltransferase (GTF) produced by mutans streptococci is the key factor in this process. Oral bacterial GTFs use sucrose as a substrate in synthesis of either water-soluble or insoluble glucans. In this investigation, kinetic studies with divalent metal ions revealed their strong binding affinity to GTF. The metal ions also proved to be strong inhibitors of the enzyme. Here we describe a simple method of inactivating the enzyme that actively participates in dental caries by taking advantage of a Fenton reaction which requires metal ions such as iron or copper and peroxide. The hydroxyl radical ions produced via the Fenton reaction inactivate GTF, a factor in the production of dental caries.

References

Apr 1, 1979·Journal of Clinical Periodontology·J Wennström, J Lindhe
Jan 1, 1979·Methods in Enzymology·W W Cleland
May 1, 1986·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Feb 1, 1983·Infection and Immunity·E L ThomasA K Chwang
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Jan 7, 1998·Protein Science : a Publication of the Protein Society·K S DevulapalleG Mooser
Jan 27, 1999·Nature Biotechnology·C G KellyT Lehner

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Citations

Oct 20, 2004·Oral Microbiology and Immunology·K MitrakulN Ganeshkumar
Jul 14, 2012·Brazilian Oral Research·Cecília Cláudia Costa RibeiroJaime Aparecido Cury
May 14, 2016·BMC Oral Health·Jinpu ChuKexin He
Jan 1, 2005·Food Science and Technology Bulletin·Peter W TaylorPaul D Stapleton
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter W Taylor

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