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Glucuronide conjugation reduces the cytotoxicity but not the mutagenicity of benzo(a)pyrene in the CHO/HGPRT assay

Teratogenesis, Carcinogenesis, and Mutagenesis

Jan 1, 1984

Leslie Recio, A W Hsie

PMID: 6150556

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Abstract

Benzo(a)pyrene (B[a]P) is biotransformed by the mixed-function oxidase (MFO) system to numerous metabolites some of which are cytotoxic and/or mutagenic to mammalian cells. However, conjugation of B(a)P metabolites with glucuronic acid in vivo is a major pathway of detoxication and elim...read more

Mentioned in this Paper

Glucuronic Acids
Ovary
Benzo(a)pyrene
Structure-Activity Relationship
Mixed Function Oxygenases
Cricetulus
Brain Edema
Cricetus
Cell Survival
Glucuronic Acid, 6-(14)C-labeled, (D)-isomer
Paper Details
References
  • References8
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  • References8
  • Citations8
1

Glucuronide conjugation reduces the cytotoxicity but not the mutagenicity of benzo(a)pyrene in the CHO/HGPRT assay

Teratogenesis, Carcinogenesis, and Mutagenesis

Jan 1, 1984

Leslie Recio, A W Hsie

PMID: 6150556

DOI:

Abstract

Benzo(a)pyrene (B[a]P) is biotransformed by the mixed-function oxidase (MFO) system to numerous metabolites some of which are cytotoxic and/or mutagenic to mammalian cells. However, conjugation of B(a)P metabolites with glucuronic acid in vivo is a major pathway of detoxication and elim...read more

Mentioned in this Paper

Glucuronic Acids
Ovary
Benzo(a)pyrene
Structure-Activity Relationship
Mixed Function Oxygenases

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Paper Details
References
  • References8
  • Citations8
  • References8
  • Citations8
1

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