PMID: 11335070May 4, 2001Paper

Glufosinate ammonium induces convulsion through N-methyl-D-aspartate receptors in mice

Neuroscience Letters
N MatsumuraT Nakaki

Abstract

Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N-methyl-D-asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors.

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Jan 8, 1990·Brain Research·M J Croucher, H F Bradford
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Mar 10, 1998·Human & Experimental Toxicology·T Watanabe, T Sano

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Citations

Feb 17, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Tae Oh JeongSeung Bae Hwang
Apr 7, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yan-Chiao MaoChen-Chang Yang
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·John E Casida
Jul 17, 2015·Human & Experimental Toxicology·J M Moon, B J Chun
Jul 5, 2018·Human & Experimental Toxicology·J H Lee, Y W Kim
Nov 23, 2013·Journal of Korean Medical Science·Jae-seok ParkSae-yong Hong
Feb 14, 2008·The Journal of Pharmacology and Experimental Therapeutics·Nobuko MatsumuraToshio Nakaki
Jul 17, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Seonghoon YeonYong Sung Cha

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