Glutamate-activated ionic currents in cultured astrocytes from trout: evidence for the occurrence of non-N-methyl-D-aspartate receptors

Journal of Neuroscience Research
T ClasenT Krüppel

Abstract

Glutamate-induced currents were recorded from cultured trout astrocytes with the whole-cell variation of the patch-clamp technique. Ninety percent of the tested cells were directly depolarized by the amino acid neurotransmitter in a concentration-dependent manner. The depolarizing effect was due to an inward current that reversed near 0 mV and was accompanied by a noise increase, indicating the opening of an ion channel. Ion substitution experiments revealed that the glutamate-induced current was mainly carried by sodium ions but not chloride or calcium ions. The glutamate-induced response could be mimicked by the neuronal glutamate receptor subtype agonists kainate and quisqualate, while N-methyl-D-aspartate was without detectable effect.

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Citations

Jul 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E Fleischer-LambropoulosA Vernadakis
Dec 9, 2003·Journal of Neuroscience Methods·T Houalla, R L Levine
Apr 27, 2000·Neuroscience and Biobehavioral Reviews·P R LamingK Ng
Jun 1, 1996·Progress in Neurobiology·A Vernadakis
Nov 21, 2002·The Journal of Comparative Neurology·Jeffrey G Edwards, William C Michel
Feb 13, 2001·Physiological Genomics·J M MarkertD J Benos

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