Glutamate Activity Regulates and Dendritic Development of J-RGCs

Frontiers in Cellular Neuroscience
Eerik EliasNing Tian

Abstract

Retinal ganglion cells (RGCs) have a wide variety of dendritic architectures, which are critical for the formation of their function-specific synaptic circuitry. The developmental regulation of the dendrites of RGCs is thought to be subtype dependent. The purpose of this study is to characterize the dendritic development of a genetically identified RGC subtype, JamB RGCs (J-RGCs), and the roles of glutamate receptor activity on the dendritic development of these cells. We show that the dendrites of J-RGCs are strictly ramified in the outer portion of the inner plexiform layer (IPL) of the retina at the age of postnatal day 8 (P8), mimicking the ramification pattern of adults. However, several other important features of dendrites undergo substantial developmental refinement after P8. From P8 to P13, the dendritic development of J-RGCs is characterized by a dramatic increase of dendritic length and the size of the dendritic field. After eye opening, the dendritic development of J-RGCs is characterized by a tremendous decrease of the number of dendritic protrusions (spine-like structures) and a consolidation of the size of the dendritic field. To determine whether the dendritic development of J-RGCs is regulated by glutamatergic ...Continue Reading

References

Jul 23, 1981·Nature·H WässleB B Boycott
Apr 15, 1999·Annual Review of Neuroscience·R O Wong
Dec 14, 1999·The European Journal of Neuroscience·G NaseH Monyer
Sep 28, 2000·Cerebral Cortex·A K McAllister
Oct 29, 2000·Science·M HäusserG J Stuart
Apr 3, 2001·The Journal of Comparative Neurology·R G PourchoD J Goebel
Jun 26, 2001·Progress in Brain Research·Z J Zhou
Jul 18, 2001·Brain Research. Molecular Brain Research·J Xue, N G Cooper
Aug 31, 2001·Nature Neuroscience·R H Masland
Jun 8, 2002·Annual Review of Neuroscience·Kristin L WhitfordAnirvan Ghosh
Sep 5, 2002·The Journal of Comparative Neurology·Wenzhi SunShigang He
Sep 5, 2002·The Journal of Comparative Neurology·Sara Louise HebbelerDale Robert Sengelaub
Oct 3, 2002·Nature Reviews. Neuroscience·Rachel O L Wong, Anirvan Ghosh
Nov 25, 2003·Histochemistry and Cell Biology·Olga Lèvai, Jörg Strotmann
Feb 6, 2004·Nature Neuroscience·Cristopher M NiellStephen J Smith
Jul 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elke GuentherKonrad Kohler
Nov 24, 2004·The Journal of Comparative Neurology·Tudor Constantin Badea, Jeremy Nathans
Feb 16, 2005·Nature Neuroscience·Christian LohmannTobias Bonhoeffer
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Jen LeeReha S Erzurumlu
Aug 10, 2005·The Journal of Cell Biology·Zhen HuangLouis F Reichardt
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca C StacyRachel O L Wong
Apr 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda S Overstreet-WadicheGary L Westbrook
Mar 24, 2007·Annual Review of Neuroscience·Jay Z ParrishYuh Nung Jan
May 12, 2007·The Journal of Comparative Neurology·Hong-Ping Xu, Ning Tian
Jun 16, 2007·The Journal of Comparative Neurology·Julie L CoombsLeo M Chalupa
Dec 4, 2008·The Journal of Comparative Neurology·Béla VölgyiStewart A Bloomfield
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun Zhang, Jeffrey S Diamond
Aug 21, 2009·Nature·Daniel KerschensteinerRachel O L Wong
Jan 1, 2010·Investigative Ophthalmology & Visual Science·Yun-Chieh ChangChuan-Chin Chiao
Jan 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·In-Jung KimJoshua R Sanes
Jan 29, 2010·Journal of Neurophysiology·Anastacia AnishchenkoE J Chichilnisky

❮ Previous
Next ❯

Citations

Sep 13, 2019·International Journal of Molecular Sciences·Carlos G Martinez-MorenoCarlos Arámburo
Jan 12, 2021·Current Opinion in Pharmacology·Jessica PaganoCarlo Sala

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
confocal microscopy
Scanning Microscopy
transgenic

Software Mentioned

Igor
Neurolucida
Adobe Photoshop
STATVIEW
IPLab
Neurolucida 2000

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.