Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy

Epilepsy Research
T L BabbP A Kuhlman

Abstract

The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of the fascia dentata and aberrant mossy fiber neoinnervation in human and kainate rat hippocampal epilepsy. Because AMPA sub-units modulate the fast glutamate synaptic transmission, we hypothesized that the AMPA receptor densities would be related to the glutamate-secreting mossy fibers, which could then contribute to seizure generation. In human hippocampal epilepsy, we found that the immunocytochemical labeling of GluR1 and GluR2/3 dendrites was positively related to the densities and spatial locations of the densest, aberrant neo-Timm stained supragranular mossy fibers. We used quantitative densitometry for the mossy fibers. However, the relatively faint and punctate immunocytochemical staining of the receptors did not allow true quantitative densitometry of the dendritic trees because in human epilepsy granule cell densities were decreased on average 50% of normal. Nevertheless, visual observations did confirm spatial relations between dense fascia dentata inner molecular layer mossy fibers and dense AMPA receptor staining. In the outer molecular layer, the mossy fiber...Continue Reading

References

Aug 1, 1978·European Journal of Pharmacology·R SchwarczJ T Coyle
Jan 8, 1990·Brain Research·M J Croucher, H F Bradford
Jun 1, 1990·Experimental Neurology·J W GeddesC W Cotman
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C GallG Lynch
Nov 1, 1983·Electroencephalography and Clinical Neurophysiology·E A CavalheiroG F Ricci
Dec 1, 1984·Epilepsia·T L BabbP H Crandall
Jul 2, 1981·Neuroscience Letters·R ZaczekJ T Coyle
Jun 1, 1994·Current Opinion in Neurobiology·G L Westbrook
Oct 1, 1994·Neurochemistry International·D F CondorelliA M Giuffrida-Stella
Jun 27, 1994·Neuroreport·S L EastwoodP J Harrison
Jul 1, 1994·The European Journal of Neuroscience·W KamphuisF H Lopes da Silva
Jan 4, 1993·European Journal of Pharmacology·D P McLaughlinR W Kerwin

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Citations

Sep 1, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Min-Cheol LeeSeung-Up Kim
May 26, 2005·Brain Research·Simone Denise SalamoniRicardo Vaz Breda
Jun 5, 2003·Neurotoxicology·G Jean Harry, Christian Lefebvre d'Hellencourt
May 19, 2001·Neurologic Clinics·I NajmD Janigro
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Oct 9, 1999·Epilepsy Research·I BlümckeO D Wiestler
Sep 22, 2000·Epilepsia·K M JacobsD A Prince
Jul 23, 1999·Annals of the New York Academy of Sciences·J R Stevens
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei ZhangPaul S Buckmaster
Dec 20, 2005·Brain Research·Adnan H Siddiqui, Shirley A Joseph
Nov 5, 2013·Neuroscience and Biobehavioral Reviews·Maxime Lévesque, Massimo Avoli
Apr 29, 2008·Epilepsy & Behavior : E&B·Joao Carlos M MarinMarcos T Mercadante
Jul 15, 2020·Epilepsia·Thaís Caroline Dallabona DombroskiAntonio Roberto Martins
May 1, 2021·International Journal of Molecular Sciences·Elisa Ren, Giulia Curia
Jan 5, 2002·Neurosurgery Clinics of North America·Zhong Ying, Imad M Najm

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