PMID: 9543187Jan 1, 1997Paper

Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring

Autoimmunity
S-A IvarssonL Svanberg

Abstract

We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmö, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.

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Citations

Mar 29, 2002·Diabetes/metabolism Research and Reviews·Marian Rewers
Apr 14, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Alberto Falorni, Annalisa Brozzetti
Jul 28, 2001·Diabetes Technology & Therapeutics·W HaoA Lernmark
Nov 13, 2001·Clinical and Experimental Immunology·A M HämäläinenUNKNOWN Finnish TRIGR Study Group
Mar 20, 2003·Current Diabetes Reports·Anu-Maaria Hämäläinen, Mikael Knip
Oct 28, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·T P LundbergD M Jensen
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Karin LarssonAke Lernmark
Nov 30, 2010·Journal of Reproductive Immunology·Sabina Resic LindehammerUNKNOWN Diabetes Prediction in Skåne (DiPiS) Study Group
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Hélène WucherJosé Timsit
Jun 23, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A LapollaD Fedele
Nov 12, 2013·Pediatric Diabetes·Cecilia AnderssonUNKNOWN Better Diabetes Diagnosis Study Group
Feb 15, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·K F LynchUNKNOWN Diabetes Prediction in Skåne (DiPiS) Study Group

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