Glutamate decarboxylase-immunoreactive terminals of Golgi-impregnated axoaxonic cells and of presumed basket cells in synaptic contact with pyramidal neurons of the cat's visual cortex

The Journal of Comparative Neurology
T F FreundP Somogyi

Abstract

Glutamate decarboxylase (GAD)-immunoreactive varicosities were found around cell bodies of nonimmunoreactive and immunoreactive neurons in the cat's visual cortex; they also occurred along apical dendrites and axon initial segments of pyramidal neurons. By examination in the electron microscope of structures first identified in the light microscope, it was established that the GAD-immunoreactive varicosities were boutons in symmetrical synaptic contact with pyramidal cells in layers II-IV. More than 90% of 142 boutons surrounding the cell bodies of 20 pyramidal neurons were immunoreactive for GAD. Since such a high proportion of the axosomatic boutons are GAD-immunoreactive, it is likely that the terminals of basket cells are included in this population and so the basket cell probably uses gamma-aminobutyrate as a transmitter, as suggested by previous authors. Almost all the 68 boutons in symmetrical contact with the axon initial segments of six pyramidal neurons could be shown to be GAD-immunoreactive, which makes it very likely that the boutons of axoaxonic cells contain GAD-immunoreactivity. This was established unequivocally for an individual Golgi-impregnated axoaxonic cell by combining Golgi impregnation and immunocytoche...Continue Reading

References

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Citations

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Oct 24, 2000·The Journal of Comparative Neurology·C De La Roza, F Reinoso-Suárez
Jan 1, 1992·Biological cybernetics·P PattonR E Wyatt
Jan 1, 1986·Anatomy and Embryology·F Valverde, M V Facal-Valverde
Jan 1, 1986·Experimental Brain Research·Z F KisvárdayP Somogyi
Sep 1, 1993·Journal of Neurocytology·M E Dennison-CavanaghJ G Parnavelas
May 1, 1994·Journal of Neurocytology·D L BensonG Banker
Jan 1, 1993·Journal of Neuroscience Methods·D M Sherry, S Yazulla
Apr 1, 1990·Brain Research. Developmental Brain Research·C Beaulieu, M Cynader
Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
Nov 1, 1987·Neuroscience·H E Scharfman, J M Sarvey

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