PMID: 856413Apr 22, 1977

Glutamate decarboxylase localization in neurons of the olfactory bulb

Brain Research
C E RibakE Roberts

Abstract

Glutamate decarboxylase (GAD), the enzyme that synthesizes the neurotransmitter gamma-aminobutyric acid (GABA), has been localized in the rat olfactory bulb by immunocytochemical methods with both light and electron microscopy. The light microscopic results demonstrated GAD-positive puncta concentrated in the external plexiform layer and in the glomeruli of the glomerular layer. In addition, GAD-positive reaction product stained the dentrites and somata of granule and periglomerular cells. The electron microscopic observations confirmed the presence of GAD-positive reaction product within granule and periglomerular somata and dendrites. In electron micrographs of the external plexiform layer, the gemmules which arise from the distal dentrites of granule cells were also observed to be filled with reaction product, and these structures corresponded in size and location to the puncta observed in light microscopic preparations. The gemmules were observed to form reciprocal dendrodentritic synaptic junctions with mitral cell dentrites which lacked reaction product. In the glomeruli, GAD-positive reaction product was observed in the dentritic shafts and gemmules of periglomerular cells which also formed reciprocal dendrodentritic syn...Continue Reading

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Citations

Dec 1, 1975·The Journal of Comparative Neurology·B J McLaughlinJ Y Wu
Oct 1, 1975·The Journal of Physiology·T V Getchell, G M Shepherd
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K SaitoJ E Vaughn
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Related Concepts

Metabolic Process, Cellular
Establishment and Maintenance of Localization
Structure of Olfactory Bulb
Malignant Neoplasm of Spinal Cord
Neurons
Brain
Renal Glomerular Disease
Immune Sera
Glutamate Decarboxylase
Aplasia of Lacrimal and Salivary Glands

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