PMID: 589307Dec 10, 1977

Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic

British Medical Journal
L Van Waes, C S Lieber

Abstract

The usefulness of blood enzyme determinations as markers of liver necrosis was tested in 100 alcoholics who underwent biopsy during clinical investigation. Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyltransferase (OCT), and gamma-glutamyltranspeptidase (gamma-GTP) tended to rise with increasing liver cell necrosis, though values of SGOT, SGPT, OCT, and gamma-GTP showed considerable overlap between the 32 patients with histologically proved hepatitis and the 68 without. By contrast, GDH values showed virtually no overlap between patients with and without hepatitis, and a value of two and a half times the normal value discriminated between the two groups. Because of its easy determination and its reliable reflection of liver cell necrosis the GDH concentration should be estimated routinely in alcoholic patients.

References

Apr 11, 1977·Biochemical and Biophysical Research Communications·Rolf TeschkeG Strohmeyer
May 20, 1972·Lancet·J Spencer-PeetM M Glatt
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki, D Rau
Oct 28, 1961·British Medical Journal·A G BECKETTK R HILL

Citations

Mar 15, 1983·Klinische Wochenschrift·M Nishimura, Rolf Teschke
Dec 1, 1988·Digestive Diseases and Sciences·J J Reichling, M M Kaplan
Aug 15, 1984·Biochemical Pharmacology·Rolando Hernández-MuñozV Chagoya de Sánchez
Nov 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A J HusseyG J Beckett
Feb 22, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·J WeillA M Le Goff
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·H G PeltenburgW T Hermens
May 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg, B M Kapur
Aug 1, 1993·Clinical Biochemistry·E Schmidt, F W Schmidt
May 1, 1985·Alcohol·S TakaseY Matsuda
Apr 20, 1978·The New England Journal of Medicine·C S Lieber
Jan 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shelli SchomakerJiri Aubrecht
Nov 26, 2009·Infection and Immunity·B ManivannanA C La Flamme
Feb 1, 1982·Journal of Clinical Pathology·W J JenkinsS Sherlock
Apr 1, 1983·Journal of Clinical Pathology·V Marks
Jan 1, 1991·Drug and Alcohol Review·C S Lieber
Jul 1, 1984·Digestive Diseases and Sciences·I G RennerR L Peters
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S CauletE Martin
Jan 1, 1992·Critical Reviews in Clinical Laboratory Sciences·S W French
Sep 1, 1989·Scandinavian Journal of Gastroenterology·M Salaspuro
Apr 1, 1990·Alcoholism, Clinical and Experimental Research·R TsutsumiC S Lieber
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·C S Lieber
Jan 23, 2016·Oxidative Medicine and Cellular Longevity·Martha Lucinda Contreras-Zentella, Rolando Hernández-Muñoz
Dec 23, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroshi MurayamaMasaru Hamaoki
Oct 1, 2008·Journal of Gastroenterology and Hepatology·Hiroshi MurayamaAtsuo Nagata
Sep 1, 1984·The American Journal of Medicine·B PeterssonB Hood
Nov 1, 1978·The American Journal of Medicine·C S Lieber
Oct 1, 1989·Alcoholism, Clinical and Experimental Research·F SchellenbergJ Weill
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B NalpasP Berthelot
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber
Mar 1, 1980·British Journal of Addiction·M Davis
Jan 1, 1981·Annals of the New York Academy of Sciences·C S Lieber
Oct 1, 1980·Alcoholism, Clinical and Experimental Research·T M Worner, C S Lieber
Jul 1, 1978·Clinics in Endocrinology and Metabolism·R Fink, S B Rosalki
Apr 2, 1999·Biochimica Et Biophysica Acta·S GüldütunaU Leuschner
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·D P AgarwalH W Goedde
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S PolR Barouki
Apr 26, 2017·Experimental Biology and Medicine·Olivia Vázquez-MartínezMauricio Díaz-Muñoz
May 1, 1982·Circulation·V F Froelicher
Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberM A Leo
Apr 28, 1984·British Medical Journal·B PeterssonB Hood
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·T SuematsuH Abe
Oct 1, 1979·Alcoholism, Clinical and Experimental Research·S ShawC S Lieber
May 1, 1982·Circulation·J B SaundersA Paton
Dec 1, 1982·Liver·I J KronborgI R Mackay
Feb 22, 2020·Frontiers in Pharmacology·Siyu FuTaoyou Zhou
Jan 1, 1980·Acta Medica Scandinavica·J Carlson, S Eriksson

Related Concepts

Alcohol Abuse
Biopsy
Glutamate Dehydrogenase
Liver Dysfunction
Necrosis
Transferase
Drug-Induced Acute Liver Injury

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