PMID: 9017909Dec 1, 1996

Glutamate dehydrogenase antigen detection in Plasmodium falciparum infections

The Korean Journal of Parasitology
N de Dominguez, A Rodríguez-Acosta

Abstract

The usefulness of malaria diagnosis by Plasmodium falciparum GDH (NADP+), obtained by affinity chromatography, is demonstrated in ELISA assays, testing IgG antibodies against GDH (NADP+) from patients with acute malaria, who have had two or more episodes of malaria, or from sera of hyperimmune patients. GDH (NADP+) thermal stability was demonstrated in a high heat resistance assay. The immunofluorescence assay demonstrated that anti-culture (P. falciparum) supernatant serum and anti-GDH (NADP+) of Proteus spp. recognized epitopes in Venezuelan isolates, and Colombian and Brasilian malarial strains. The antigen is soluble, with high specificity, is a potent immunogen and is thermoresistant.

References

Jun 22, 1978·Nature·W Trager, J B Jenson
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Jul 26, 1969·Lancet·R J WilsonR Bartholomew
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Citations

Dec 1, 2009·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S M A AbidiM K Saifullah
Feb 26, 2005·Infection and Immunity·C HemmerEmil Christian Reisinger
Oct 30, 2014·The Korean Journal of Parasitology·Chom-Kyu ChongTong-Soo Kim
Dec 19, 2014·The Cochrane Database of Systematic Reviews·Katharine AbbaYemisi Takwoingi
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Katharine AbbaPaul Garner
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Rodríguez-AcostaM E Girón

Related Concepts

Antibodies, Protozoan
Antigens, Protozoan
Chromatography, Affinity
Ducks
Enzyme-Linked Immunosorbent Assay
Glutamate Dehydrogenase
Polyglobin
Plasmodium falciparum
Malaria, Falciparum

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