Glutamate dehydrogenases from tissues of the ribbed mussel Modiolus demissus: ADP activation and possible physiological significance

The Journal of Experimental Zoology
P M ReissS H Bishop


Glutamate dehydrogenase (E.C. 14.1.3) was localized in the mitochondria from heart, gill, mantle and hepatopancreas of this euryhaline bivalve mollusc. Activity levels were low (0.1-0.4 mumoles/min/g wet weight) in all tissues when assayed in the glutamate forming direction. Partially purified gill mitochondrial GDH was most active at pH 8.5. The rate in the glutamate deaminating direction was 10-20% of the rate in the glutamate forming direction. ADP at apparent Ka concentrations of micrometer (glutamate formation) and 170 micrometer (glutamate deamination) enhanced GDH activity, 8- and 4-fold respectively. GDH, in vivo, is probably in the activated form and appears to function in glutamate synthesis rather than ammonia formation. However, based on the low activities obtained, the role of GDH in salinity induced amino acid synthesis seems minimal.


Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S H BishopR J Hoffman
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K T PaynterS H Bishop
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y Batrel, M Regnault
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C E Cornelius
Dec 1, 1981·Journal of Morphology·John A WattsSidney K Pierce
Jan 1, 1978·The Journal of Experimental Zoology·R J HoffmannC Sassaman
May 1, 1990·Human & Experimental Toxicology·P J KostyniakE Cunningham

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