Glutamate-Dependent BMAL1 Regulation in Cultured Bergmann Glia Cells

Neurochemical Research
Donají Chi-CastañedaArturo Ortega

Abstract

Glutamate, the major excitatory amino acid, activates a wide variety of signal transduction cascades. This neurotransmitter is involved in photic entrainment of circadian rhythms, which regulate physiological and behavioral functions. The circadian clock in vertebrates is based on a transcription-translation feedback loop in which Brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like protein 1 (BMAL1) acts as transcriptional activator of others clock genes. This protein is expressed in nearly all suprachiasmatic nucleus neurons, as well as in the granular layer of the cerebellum. In this context, we decided to investigate the role of glutamate in the molecular mechanisms involved in the processes of transcription/translation of BMAL1 protein. To this end, primary cultures of chick cerebellar Bergmann glial cells were stimulated with glutamatergic ligands and we found that BMAL1 levels increased in a dose- and time dependent manner. Additionally, we studied the phosphorylation of serine residues in BMAL1 under glutamate stimulation and we were able to detect an increase in the phosphorylation of this protein. The increased expression of BMAL1 is most probably the result of a stabilization of the protein aft...Continue Reading

References

Jan 1, 1991·Neuroscience·A OrtegaV I Teichberg
Apr 1, 1993·The European Journal of Neuroscience·M CastelJ Storm-Mathisen
Jan 12, 1994·Neuroreport·T LópezA Ortega
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Sep 15, 1998·Biochemical and Biophysical Research Communications·S HonmaM Nomura
Feb 13, 1999·Cell·J C Dunlap
Dec 22, 1999·British Journal of Pharmacology·M AkiyamaS Shibata
Jun 9, 2000·Annual Review of Neuroscience·D P King, J S Takahashi
Feb 22, 2001·Annual Review of Physiology·S M Reppert, D R Weaver
May 23, 2001·Progress in Neurobiology·N C Danbolt
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·N Cermakian, P Sassone-Corsi
Mar 5, 2002·The Journal of Biological Chemistry·Erik J EideDavid M Virshup
Nov 6, 2002·Journal of Biochemistry·Naoaki Saito, Yasuhito Shirai
Dec 7, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Victoria Coutinho, Thomas Knöpfel
Jan 1, 2003·Cell·Ueli Schibler, Paolo Sassone-Corsi
Nov 16, 2004·Trends in Neurosciences·Leif Hertz, H Ronald Zielke
Dec 1, 2004·Human Reproduction Update·David J Kennaway
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Victoria Y GorbachevaMarina P Antoch
Aug 20, 2005·Science·Luca CardonePaolo Sassone-Corsi
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Sep 19, 2006·Molecular and Cellular Biology·Ilmin KwonKun Ho Lee
Nov 17, 2006·Journal of Biological Rhythms·Markus Stratmann, Ueli Schibler
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Monica Gallego, David M Virshup
Nov 13, 2007·Molecular and Cellular Neurosciences·Céline A FeilletEtienne Challet
Dec 14, 2007·Nature·Jun HirayamaPaolo Sassone-Corsi
Jul 19, 2008·Neuron Glia Biology·Esther López-BayghenArturo Ortega
Mar 31, 2009·Nature Structural & Molecular Biology·Teruya TamaruPaolo Sassone-Corsi
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jorge MendozaEtienne Challet
Sep 8, 2010·Neurochemistry International·Iliana BarreraArturo Ortega
Mar 11, 2011·Annals of the New York Academy of Sciences·Sooyoung ChungKyungjin Kim
Aug 23, 2011·Neurochemistry International·Zila Martínez-LozadaArturo Ortega
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Luoying ZhangLouis J Ptáček

❮ Previous
Next ❯

Citations

Sep 27, 2016·ASN Neuro·Donají Chi-Castañeda, Arturo Ortega
Feb 13, 2018·Neural Plasticity·Donají Chi-Castañeda, Arturo Ortega
Jul 12, 2019·Frontiers in Cellular Neuroscience·Shuchao WangKun Xiong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.