Glutamate exacerbates amyloid beta1-42-induced impairment of long-term potentiation in rat hippocampal slices

Japanese Journal of Pharmacology
Yasuhiro Nakagami, Tomiichiro Oda

Abstract

Amyloid beta (A beta) is the principal constituent of senile plaques in Alzheimer's disease patients. We investigated whether A beta and glutamate affect long-term potentiation (LTP) in rat hippocampal slices. Pretreatment with 1 microM A beta1-42 alone for 3 h slightly inhibited LTP; however, the potentiation was maintained for 60 min. Although the impairment was not observed by pretreatment with 30 microM glutamate alone for 3 h, pretreatment with A beta1-42 and glutamate impaired LTP significantly. These results raise the possibility that neurotoxicity of A beta is exacerbated by the enhancement of susceptibility to excitatory amino acids.

References

Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H Kimura, D Schubert
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Nov 11, 1999·European Journal of Pharmacology·A ItohT Nabeshima
Jun 14, 2000·Current Opinion in Neurobiology·R MalinowY Hayashi
Mar 16, 2001·Trends in Neurosciences·W L KleinC E Finch
Mar 29, 2001·Physiological Reviews·D J Selkoe

❮ Previous
Next ❯

Citations

Dec 3, 2014·Physiology & Behavior·Hakimeh SaadatiVahid Sheibani
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J RowanRoger Anwyl
Aug 31, 2011·Neurobiology of Learning and Memory·John G McCoy, Robert E Strecker
Jun 1, 2012·British Journal of Pharmacology·Wojciech Danysz, Chris G Parsons
Jun 12, 2004·The Journal of Pharmacology and Experimental Therapeutics·Rimante MinkevicieneHeikki Tanila

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.