Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen

Lipids in Health and Disease
Afaf K El-AnsaryAbeer Al-Dbass

Abstract

Rodent models may guide investigations towards identifying either environmental neuro-toxicants or drugs with neuro-therapeutic effects. This work aims to study the therapeutic effects of bee pollen on brain glutamate excitotoxicity and the impaired glutamine-glutamate- gamma amino butyric acid (GABA) circuit induced by propionic acid (PPA), a short chain fatty acid, in rat pups. Twenty-four young male Western Albino rats 3-4 weeks of age, and 45-60 g body weight were enrolled in the present study. They were grouped into four equal groups: Group 1, the control received phosphate buffered saline at the same time of PPA adminstration; Group 2, received 750 mg/kg body weight divided into 3 equal daily doses and served as acute neurotoxic dose of PPA; Group 3, received 750 mg/kg body weight divided in 10 equal doses of 75 mg/kg body weight/day, and served as the sub-acute group; and Group 4, the therapeutic group, was treated with bee pollen (50 mg/kg body weight) for 30 days after acute PPA intoxication. GABA, glutamate and glutamine were measured in the brain homogenates of the four groups. The results showed that PPA caused multiple signs of excitotoxicity, as measured by the elevation of glutamate and the glutamate/glutamine ra...Continue Reading

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Citations

Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Tauqeerunnisa SyedaClaudia Perez-Cruz
Nov 24, 2019·Antioxidants·Rodica MărgăoanDan C Vodnar
Feb 7, 2020·Neurotoxicity Research·Raju PaudelShamsher Singh
Mar 5, 2019·Biological & Pharmaceutical Bulletin·Yulan LiaoJong Hoon Ryu
Jan 16, 2021·Integrative Psychological & Behavioral Science·Raju Paudel, Shamsher Singh
Jan 29, 2021·Frontiers in Aging Neuroscience·Jessica KillingsworthR Douglas Shytle
Dec 15, 2020·Translational Neuroscience·Sarah I BukhariAfaf El-Ansary

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Methods Mentioned

BETA
ELISA

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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