Glutamate, Ornithine, Arginine, Proline, and Polyamine Metabolic Interactions: The Pathway Is Regulated at the Post-Transcriptional Level

Frontiers in Plant Science
Rajtilak MajumdarS C Minocha

Abstract

The metabolism of glutamate into ornithine, arginine, proline, and polyamines is a major network of nitrogen-metabolizing pathways in plants, which also produces intermediates like nitric oxide, and γ-aminobutyric acid (GABA) that play critical roles in plant development and stress. While the accumulations of intermediates and the products of this network depend primarily on nitrogen assimilation, the overall regulation of the interacting sub-pathways is not well understood. We tested the hypothesis that diversion of ornithine into polyamine biosynthesis (by transgenic approach) not only plays a role in regulating its own biosynthesis from glutamate but also affects arginine and proline biosynthesis. Using two high putrescine producing lines of Arabidopsis thaliana (containing a transgenic mouse ornithine decarboxylase gene), we studied the: (1) effects of exogenous supply of carbon and nitrogen on polyamines and pools of soluble amino acids; and, (2) expression of genes encoding key enzymes in the interactive pathways of arginine, proline and GABA biosynthesis as well as the catabolism of polyamines. Our findings suggest that: (1) the overall conversion of glutamate to arginine and polyamines is enhanced by increased utilizati...Continue Reading

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Citations

Mar 1, 2018·Plant & Cell Physiology·Leandro Francisco de OliveiraEny Iochevet Segal Floh
Feb 19, 2019·Journal of Food Science·Claire M KlevornSuzanne D Johanningsmeier
Sep 19, 2019·Plant & Cell Physiology·Tatyana V SavchenkoKatayoon Dehesh
Oct 6, 2019·Scientific Reports·Daniela PontiggiaBenedetta Mattei
May 28, 2019·Frontiers in Plant Science·Wei WangJi-Hong Liu
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Nov 19, 2019·Frontiers in Microbiology·Arshad RizviShekhar C Mande
Jan 26, 2020·Experimental & Molecular Medicine·Elizabeth L LieuJiyeon Kim
Feb 18, 2020·Frontiers in Plant Science·Xue-Mei QiuZhong-Guang Li
Aug 2, 2020·Archives of Microbiology·Kalyanasundaram Geetha ThanujaSivakumar Uthandi
May 28, 2019·International Journal of Molecular Sciences·Muhammad NadeemLijuan Qiu
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Apr 11, 2018·Scientific Reports·Anna MichalettiSara Rinalducci
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Feb 27, 2021·Journal of Plant Physiology·Saeed AminiKhalil Kariman
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Mar 20, 2021·The Plant Journal : for Cell and Molecular Biology·Sara BlicharzRobert Malinowski
Jul 3, 2021·International Journal of Molecular Sciences·Christopher L McGinityDavid A Wink
Oct 5, 2021·Frontiers in Plant Science·Giuseppe SabbioniGiuseppe Forlani
Dec 11, 2021·Frontiers in Plant Science·Hanqian ZhangJianjun Chen

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Methods Mentioned

BETA
transgenic
PCR
PCA

Software Mentioned

SYSTAT
Perkin
Elmer TotalChrom
Excel
MxPro

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