Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus

The Journal of Comparative Neurology
Diana E MogaJohn H Morrison

Abstract

Rasmussen's encephalitis is a childhood disease resulting in intractable seizures associated with hippocampal and neocortical inflammation. An autoantibody against the GluR3 subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors is implicated in the pathophysiology of Rasmussen's encephalitis. AMPA receptors mediate excitatory neurotransmission in the brain and contain combinations of four subunits (GluR1-4). Although the distributions of GluR1, GluR2, and GluR4 are known in some detail, the cellular distribution of GluR3 in the mammalian brain remains to be described. We developed and characterized a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in CA1 of the rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and astrocytes and in most interneurons. We quantified the intensity of GluR3 immunoreactivity in interneuron subtypes defined by their calcium-binding protein content. GluR3 immunofluorescence, but not GluR1 or GluR2 immunofluorescence, was significantly elevated in somata of parvalbumin-containing interneurons compared to pyramidal somata. Strikingly, increased GluR3 immunofluorescence was not observed in calbindin- and calr...Continue Reading

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Citations

Nov 28, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·John H AnnekenGary A Gudelsky
May 7, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guofu ShenElizabeth I Tietz
Mar 10, 2010·Brain Structure & Function·Hisaaki TakahashiDara L Dickstein
Apr 9, 2008·Molecular and Cellular Neurosciences·Erika SuzukiAmy C Arai
Dec 22, 2007·Autonomic Neuroscience : Basic & Clinical·M KimR M Bradley
Jan 9, 2007·Brain Research·Jason J RadleyJohn H Morrison
Dec 8, 2004·The European Journal of Neuroscience·Michel EybalinJean-Luc Puel
Aug 14, 2009·The European Journal of Neuroscience·Xiu Sun, Marina E Wolf
Mar 4, 2008·The European Journal of Neuroscience·Hendrik W SteenlandMin Zhuo
Dec 20, 2014·Hippocampus·Amanda L Jacob, Richard J Weinberg
Jun 5, 2015·Frontiers in Synaptic Neuroscience·Todd L Stincic, Matthew E Frerking
Aug 24, 2006·The Journal of Comparative Neurology·Jun Zhang, Jeffrey S Diamond

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