Glutamate receptor subunits expression in memory-associated brain structures: regional variations and effects of aging

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Ping LiuCynthia L Darlington

Abstract

We investigated regional variations and the effects of aging on the expression of the N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptor subunits in several memory-associated structures using Western blotting. In young adult rats, NR1, NR2A, and GluR2 levels varied between the hippocampus and parahippocampal region and between the subregions of the hippocampus. When a comparison was made between young (4-month-old) and aged (24-month-old) rats, significant decreases in NR1 expression were found in the aged ventral hippocampus and the entorhinal and postrhinal cortices. There were significant decreases in NR2A expression in the aged parahippocampal region, but not in the hippocampus. The expression of the GluR2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex. A dramatic decrease in NR1 and GluR2 expression was found in the aged CA2/3 and CA1, respectively, but there were no significant age-related changes in NR2A expression. All three subunits were expressed at a similar level in the two age groups in the prefrontal cortex. These results suggest differential expression and effects of aging on NMDA and AMPA receptor subunits in memory-associated brain ...Continue Reading

References

May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L DinermanS H Snyder
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·D M Rock, R L Macdonald
Jul 15, 1997·The Biochemical Journal·K Williams
May 12, 1998·Frontiers in Bioscience : a Journal and Virtual Library·K R Magnusson
Jan 9, 1999·Hippocampus·M B Moser, E I Moser
Mar 8, 2000·Brain Research Bulletin·W E SonntagJ K Brunso-Bechtold
Jul 13, 2000·Brain Research. Molecular Brain Research·K Eckles-SmithM D Browning
Dec 13, 2000·Brain Research. Brain Research Reviews·J C de la Torre, G B Stefano
Feb 13, 2001·Neurobiology of Aging·D A Clayton, M D Browning
Mar 1, 2002·Brain Research. Molecular Brain Research·Kathy Ruth MagnussonAnne B Young
Apr 11, 2003·Biochimica Et Biophysica Acta·Rebecca A Hillary, Anthony E Pegg
Jun 3, 2004·The Journal of Comparative Neurology·Michelle M AdamsJohn H Morrison
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Aug 4, 2004·Experimental Gerontology·P LiuD K Bilkey
Nov 6, 2004·Brain Research·Beatriz Martínez VillayandrePedro Calvo
Jan 10, 2006·Neurobiology of Aging·Kathy Ruth MagnussonJulie Supon
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Aug 2, 2006·Hippocampus·Joseph R Manns, Howard Eichenbaum
Aug 10, 2006·Cell and Tissue Research·Rolf Sprengel
Aug 11, 2006·Ageing Research Reviews·Bronwen MartinStuart Maudsley

❮ Previous
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Citations

Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ferenc Deak, William E Sonntag
Oct 1, 2009·Future Medicinal Chemistry·Cheryl A Frye
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sara N BurkeCarol A Barnes
Jan 23, 2016·Aging Cell·Chand Parvez Danka MohammedKeetae Kim
Sep 28, 2010·Physiology & Behavior·Tahmineh MotevasseliTouraj Nayer-Nouri
Jul 28, 2009·Biochimica Et Biophysica Acta·Andreas Kern, Christian Behl
Nov 27, 2015·Trends in Neurosciences·Stephanie L Leal, Michael A Yassa
Apr 9, 2010·Journal of Neurochemistry·Heather D VanGuilderWillard M Freeman
Mar 29, 2011·Neurobiology of Disease·Heather D VanGuilderWillard M Freeman
Mar 31, 2010·Neurochemistry International·Sheyla MontoriArsenio Fernández-López
Jul 23, 2013·PloS One·Wayne XuRobert Kratzke
Oct 5, 2017·Journal of Neurochemistry·Naoki NakayaStanislav I Tomarev
Jan 17, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Albert OrockFerenc Deak
Apr 26, 2017·Annual Review of Neuroscience·Xuelai FanSaul A Villeda
Jul 25, 2019·Current Medicinal Chemistry·Paola BrivioRaffaella Molteni

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