Glutamate receptors in extinction and extinction-based therapies for psychiatric illness.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Karyn M MyersMichael Davis

Abstract

Some psychiatric illnesses involve a learned component. For example, in posttraumatic stress disorder, memories triggered by trauma-associated cues trigger fear and anxiety, and in addiction, drug-associated cues elicit drug craving and withdrawal. Clinical interventions to reduce the impact of conditioned cues in eliciting these maladaptive conditioned responses are likely to be beneficial. Extinction is a method of lessening conditioned responses and involves repeated exposures to a cue in the absence of the event it once predicted. We believe that an improved understanding of the behavioral and neurobiological mechanisms of extinction will allow extinction-like procedures in the clinic to become more effective. Research on the role of glutamate-the major excitatory neurotransmitter in the mammalian brain-in extinction has led to the development of pharmacotherapeutics to enhance the efficacy of extinction-based protocols in clinical populations. In this review, we describe what has been learned about glutamate actions at its three major receptor types (N-methyl-D-aspartate (NMDA) receptors, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, and metabotropic glutamate receptors) in the extinction of condit...Continue Reading

References

Jan 1, 1975·Journal of Experimental Psychology. Animal Behavior Processes·R A Rescorla, C D Heth
May 1, 1992·Science·J J Kim, M S Fanselow
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Apr 1, 1995·The American Journal of Psychiatry·B O RothbaumM North
Jun 1, 1996·Behavioral Neuroscience·J D Baker, J L Azorlosa
Dec 23, 1998·Psychopharmacology·J A Harris, R F Westbrook
Jul 22, 1999·Annals of the New York Academy of Sciences·R A Nicoll, R C Malenka
Sep 15, 1999·Nature·Y P TangJ Z Tsien
May 11, 2000·Psychopharmacology·L StinusG F Koob
Jun 9, 2000·Annual Review of Neuroscience·W Schultz, A Dickinson
Dec 2, 2000·Nature Neuroscience·E C BeattieR C Malenka
Mar 10, 2001·Reviews in the Neurosciences·C C Huang, K S Hsu
Feb 28, 2002·Addiction·Cynthia A Conklin, Stephen T Tiffany
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Jun 14, 2002·Physiology & Behavior·Paula M Millin, David C Riccio
Jul 10, 2002·Annals of the New York Academy of Sciences·José A CrespoE Ambrosio
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Nov 26, 2002·Trends in Neurosciences·William A Carlezon, Eric J Nestler
Apr 24, 2003·Behavioral Neuroscience·Lana LedgerwoodJacquelyn Cranney
Jun 24, 2003·Neuron·María Eugenia Pedreira, Héctor Maldonado
Jul 29, 2003·Learning & Behavior·Robert A Rescorla
Aug 23, 2003·Science·Mark EisenbergYadin Dudai
Mar 6, 2004·Annals of the New York Academy of Sciences·Barbara Olasov Rothbaum, Michael Davis
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinobu SuzukiSatoshi Kida
May 28, 2004·Psychopharmacology·Douglas C BrooksAmanda M Woods
Jun 4, 2004·Behavioral Neuroscience·Lana LedgerwoodJacquelyn Cranney
Jun 19, 2004·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Andrew R Delamater
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edwin SantiniGregory J Quirk

❮ Previous
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Citations

Apr 27, 2011·Molecular Psychiatry·P W Kalivas, N D Volkow
Jul 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael A Benneyworth, Joseph T Coyle
Sep 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cindy Achat-MendesRoger D Spealman
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jose Rodriguez-RomagueraGregory J Quirk
Apr 26, 2012·Genes, Brain, and Behavior·R Andero, K J Ressler
Apr 14, 2012·Science·Amy L Milton, Barry J Everitt
Oct 1, 2011·Science Translational Medicine·Daniel C JavittChi-Ming Lee
Feb 22, 2012·Journal of Psychopharmacology·Floris KlumpersJohanna M P Baas
Apr 2, 2013·Cellular and Molecular Life Sciences : CMLS·R C Agis-Balboa, A Fischer
Sep 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin K OgdenScott A Heldt
Jan 1, 2012·ISRN Toxicology·R M Kuzeff
Dec 2, 2011·Annual Review of Psychology·Mohammed R Milad, Gregory J Quirk
Jan 19, 2016·Neurobiology of Learning and Memory·Ferzin Sethna, Hongbing Wang
Mar 17, 2015·Expert Opinion on Investigational Drugs·Benjamin J RagenAlexander Neumeister
Apr 9, 2014·Expert Opinion on Drug Discovery·Rebecca L Ashare, Heath D Schmidt
Oct 6, 2012·European Journal of Pharmacology·Takeshi IzumiMitsuhiro Yoshioka
Jul 20, 2012·Trends in Pharmacological Sciences·Mark A GeyerRené S Kahn
May 15, 2012·Biological Psychiatry·Karyn M Myers, William A Carlezon
Dec 18, 2014·The Journal of Sexual Medicine·Mirte BromStephanie Both
Apr 20, 2012·Acta histochemica·Wen FanYin Shen
Jul 9, 2011·Neuropharmacology·Thomas Steckler, Victoria Risbrough
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Riaza Bermudo-SorianoEnrique Baca-Garcia
May 12, 2011·Pharmacology, Biochemistry, and Behavior·Kathleen T BradyBryan K Tolliver
May 4, 2011·Pharmacology, Biochemistry, and Behavior·M Foster OliveRobert J Malcolm
Aug 4, 2015·Psychiatric Annals·Christopher Pittenger
Oct 9, 2015·Neuron·Joseph E DunsmoorElizabeth A Phelps
Dec 24, 2010·British Journal of Pharmacology·Bronwyn M GrahamRick Richardson
Aug 22, 2015·Psychopharmacology·Daisuke NishiYutaka Matsuoka
Apr 23, 2014·British Journal of Pharmacology·Christina J PerryAndrew J Lawrence
Jun 18, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jihye KimSukwoo Choi
May 21, 2015·Journal of Traumatic Stress·Lisa J Cohen, David Brody
Mar 22, 2014·Biochemical Society Transactions·Nigel Whittle, Nicolas Singewald
Sep 13, 2014·Journal of Behavioral Addictions·Liana R N SchreiberJon E Grant

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