Glutamate receptors in tendinopathic patients

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Nikos SchizasPaul W Ackermann

Abstract

Tendinopathy, pain, and degeneration, may be related to the up-regulation of substance P (SP) and its activation of glutamate receptors. We hypothesized that the pathogenesis of tendinopathy involves N-methyl-D-aspartate receptor type 1 (NMDAR1) activation (phosphorylated NMDAR1; phospho-NMDAR1) co-existing with SP. Moreover, we examined the presence of metabotropic receptors that increase (mGluR1 and mGluR5) or decrease (mGluR6 and mGluR7) NMDAR1 excitability. Biopsies from patients with patellar tendinopathy (n = 10) and from controls (n = 8) were immunohistochemically analyzed according to the occurrence and tissue distribution of NMDAR1, phosho-NMDAR1, mGluR (1, 5-7), and SP. The biopsies were immunohistochemically single- and double-stained and semi-quantitatively assessed. Tendinopathic biopsies exhibited increased occurrence of NMDAR1, phospho-NMDAR1, SP, and mGluR5, while mGluR6-7 were not increased and mGluR1 was not found. The occurrence of NMDAR1 and SP correlated in tendinopathy (r(2)  = 0.54, p = 0.03), but not in the controls (r(2)  = 0.11, p = 0.4). Co-localization of SP and phospho-NMDAR1 within the tendon proper was only found in tendinopathy, localized on hypertrophic tenocytes, blood vessels, and penetrating ...Continue Reading

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Citations

Sep 13, 2013·Sports Medicine·Ebonie RioJill Cook
May 31, 2013·International Journal of Experimental Pathology·Paul W Ackermann
Apr 13, 2013·Journal of Cellular and Molecular Medicine·Ludvig J Backman, Patrik Danielson
Sep 28, 2015·Clinics in Sports Medicine·Nicola MaffulliFrancesco Oliva
Sep 3, 2013·British Journal of Sports Medicine·Ludvig J BackmanPatrik Danielson
Aug 20, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kars P ValkeringPaul W Ackermann
May 30, 2014·The American Journal of Sports Medicine·Sarah L FranklinAndrew J Carr
Jun 24, 2017·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Simon SvedmanPaul W Ackermann
Oct 24, 2018·Open Forum Infectious Diseases·Thomas LodiseSue Cammarata
Nov 17, 2020·Journal of Shoulder and Elbow Surgery·Bassmh Abdullah A Al-DhaferJae Kwang Kim

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