PMID: 9550192Apr 29, 1998Paper

Glutamate receptors in the mammalian central nervous system

Progress in Neurobiology
S OzawaK Tsuzuki

Abstract

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the mammalian central nervous system (CNS). In addition, they are involved in plastic changes in synaptic transmission as well as excitotoxic neuronal cell death that occurs in a variety of acute and chronic neurological disorders. The GluRs are divided into two distinct groups, ionotropic and metabotropic receptors. The ionotropic receptors (iGluRs) are further subdivided into three groups: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), kainate and N-methyl-D-aspartate (NMDA) receptor channels. The metabotropic receptors (mGluRs) are coupled to GTP-binding proteins (G-proteins), and regulate the production of intracellular messengers. The application of molecular cloning technology has greatly advanced our understanding of the GluR system. To date, at least 14 cDNAs of subunit proteins constituting iGluRs and 8 cDNAs of proteins constituting mGluRs have been cloned in the mammalian CNS, and the molecular structure, distribution and developmental change in the CNS, functional and pharmacological properties of each receptor subunit have been elucidated. Furthermore, the obtained clones have provided valuable tools for conducting studies...Continue Reading

References

Jan 1, 1992·Neuron·Y TanabeS Nakanishi
Jul 28, 1992·FEBS Letters·H LomeliP H Seeburg
Aug 1, 1992·Neuron·B LambolezJ Rossier
Apr 22, 1992·European Journal of Pharmacology·Z A Bortolotto, G L Collingridge
Jun 30, 1992·Biochemical and Biophysical Research Communications·H SugiharaS Nakanishi
Nov 27, 1992·Science·J D ClementsG L Westbrook
Apr 15, 1992·The Journal of Comparative Neurology·R S Petralia, R J Wenthold
Jul 2, 1992·Nature·T KutsuwadaM Arakawa
Jun 5, 1992·European Journal of Pharmacology·C ChiamuleraA Reggiani
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P PinS F Heinemann
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroW A Pulsinelli
Mar 23, 1992·FEBS Letters·M YamazakiM Mishina
May 17, 1991·European Journal of Pharmacology·N McGuinnessM Rowan
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J Y KohC W Cotman
Oct 31, 1991·Biochemical and Biophysical Research Communications·M MishinaK Nagahari
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S Isaacson, R A Nicoll
Dec 3, 1991·European Journal of Pharmacology·S Otani, Y Ben-Ari
Mar 22, 1991·Proceedings. Biological Sciences·S Charpak, B H Gähwiler

❮ Previous
Next ❯

Citations

Feb 19, 1999·The Journal of Comparative Neurology·A A Montague, C A Greer
Jun 16, 2001·Journal of Cellular Biochemistry·C ItzsteinC Chenu
Jan 1, 2003·Indian Journal of Clinical Biochemistry : IJCB·Rama Devi MittalKailash Nath Agarwal
Jul 1, 2002·Indian Journal of Clinical Biochemistry : IJCB·Rama Devi MittalKailash Nath Agarwal
Jul 2, 2003·Neurotoxicity Research·Thomas N ChaseJustin D Oh
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Sep 13, 2011·Journal of Neurology·Maria B Lauvsnes, Roald Omdal
May 28, 2011·Journal of Neural Transmission·József KaszakiMihály Boros
Jul 21, 2009·Modern Rheumatology·Petros Efthimiou, Michelle Blanco
Jun 13, 2006·Japanese Journal of Ophthalmology·Atsuya MikiYasuo Tano
Sep 1, 2005·Cellular and Molecular Neurobiology·Marcos Emílio FrizzoDiogo Onofre Souza
May 7, 2005·Neuroscience and Behavioral Physiology·A V Sem'yanov
May 27, 2005·Journal of Biomedical Science·Li Hsueh Tsai
Mar 17, 2001·Current Pain and Headache Reports·M S Wallace
Jan 15, 2003·Current Pain and Headache Reports·Eric Chevlen
Sep 18, 2007·Journal of Molecular Neuroscience : MN·Frank I TaraziJean-François Liégeois
Apr 3, 2009·The Journal of Physiological Sciences : JPS·Takuya HikimaHiromu Yawo
Mar 28, 2013·Neurotoxicity Research·Arik EisenkraftArseny Finkelstein
Mar 23, 2005·Brain Research·Fernanda Bossemeyer CenturiãoJoão Batista Teixeira Rocha
Sep 30, 2008·Brain Research·Xiao-Dong JiangPei-Ji Liang
Nov 15, 2003·Journal of Chemical Neuroanatomy·Renato F SantanaCláudio A B Toledo
Jan 7, 2004·Journal of the Neurological Sciences·Débora JunqueiraMoacir Wajner
Mar 31, 2004·Molecular Aspects of Medicine·Ana LedoJoão Laranjinha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.