PMID: 16646155May 2, 2006Paper

Glutamate release from astrocytes as a non-synaptic mechanism for neuronal synchronization in the hippocampus

Journal of Physiology, Paris
Giorgio Carmignoto, Tommaso Fellin

Abstract

Synchronization of activity of anatomically distributed groups of neurons represents a fundamental event in the processing of information in the brain. While this phenomenon is believed to result from dynamic interactions within the neuronal circuitry, how exactly populations of neurons become synchronized remains largely to be clarified. We propose that astrocytes are directly involved in the generation of neuronal synchrony in the hippocampus. By using a combination of experimental approaches in hippocampal slice preparations, including patch-clamp recordings and confocal microscopy calcium imaging, we studied the effect on CA1 pyramidal neurons of glutamate released from astrocytes upon various stimuli that trigger Ca2+ elevations in these glial cells, including Schaffer collateral stimulation. We found that astrocytic glutamate evokes synchronous, slow inward currents (SICs) and Ca2+ elevations in CA1 pyramidal neurons by acting preferentially, if not exclusively, on extrasynaptic NMDA receptors. Due to desensitization, AMPA receptors were not activated by astrocytic glutamate unless cyclothiazide was present. In the virtual absence of extracellular Mg2+, glutamate released from astrocytes was found to evoke, in paired reco...Continue Reading

References

Aug 1, 1990·Trends in Pharmacological Sciences·R DingledineJ O McNamara
Jun 30, 1994·Nature·V ParpuraP G Haydon
Dec 1, 1996·Epilepsy Research·M Khurgel, G O Ivy
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·D E BerglesC E Jahr
Sep 30, 1998·The European Journal of Neuroscience·A AraqueP G Haydon
May 14, 1999·Trends in Neurosciences·A AraqueP G Haydon
Jul 6, 2000·Progress in Neurobiology·G Carmignoto
Mar 21, 2001·Nature Reviews. Neuroscience·P G Haydon
Nov 5, 2002·The Journal of Biological Chemistry·Silvia CocoClaudia Verderio
Aug 2, 2003·Nature·Kenneth D HarrisGyörgy Buzsáki
Oct 3, 2003·Trends in Neurosciences·Eric A Newman
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Todd A Fiacco, Ken D McCarthy
Jun 26, 2004·The Journal of Physiology·Tommaso Fellin, Giorgio Carmignoto
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·María Cecilia AnguloEtienne Audinat
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jul 19, 2005·Nature Reviews. Neuroscience·Andrea Volterra, Jacopo Meldolesi
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard

❮ Previous
Next ❯

Citations

Aug 12, 2009·Journal of Biological Physics·Renato Nobili
Jun 5, 2013·Journal of Biological Physics·Shivendra G Tewari, Kaushik Kumar Majumdar
Nov 19, 2010·PLoS Computational Biology·Suhita NadkarniHerbert Levine
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy PetraviczKen D McCarthy
Aug 30, 2014·Journal of Physiology, Paris·R Moraga-AmaroJ Stehberg
Jul 1, 2012·Translational Stroke Research·Sangeetha Sukumari-RameshKrishnan M Dhandapani
Dec 24, 2015·Frontiers in Cellular Neuroscience·Balázs Pál
Mar 10, 2016·Neurobiology of Disease·Meera RamaniPeter L Carlen
Dec 25, 2007·Biological Psychiatry·Akin Oni-OrisanRobert E McCullumsmith
Jul 17, 2008·Journal of Neurochemistry·Jun-Wei ZengHuai-Zhen Ruan
Aug 16, 2008·The European Journal of Neuroscience·Takayuki SuzukiHiroyoshi Miyakawa
Feb 15, 2012·Glia·Eleonora AronicaAnnamaria Vezzani
May 3, 2015·IEEE Transactions on Biomedical Circuits and Systems·Yilda Irizarry-Valle, Alice Cline Parker
Mar 3, 2009·Gastroenterology·Brian D Gulbransen, Keith A Sharkey
Nov 14, 2012·Epilepsy & Behavior : E&B·Julián TejadaNorberto Garcia-Cairasco
Dec 3, 2014·Neuropharmacology·Annamaria Vezzani, Barbara Viviani
Sep 21, 2007·Neurochemistry International·Alexey Semyanov
Sep 23, 2014·Neuropharmacology·Marianela Garcia-MunozGordon W Arbuthnott
Jul 6, 2010·Toxicology and Applied Pharmacology·Shin-ichi SekizawaAnn C Bonham
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·L G Khaspekov, L E Frumkina
Mar 13, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Vincenzo CrunelliChristian Steinhäuser
Sep 16, 2016·Neural Plasticity·Francisco J CarvajalWaldo Cerpa
Jun 23, 2007·The Journal of Biological Chemistry·Jun XuJian Kang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.