Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease.

Neuropharmacology
Sonia SpitzerRagnhildur Káradóttir

Abstract

Myelin is essential for the mammalian brain to function efficiently. Whilst many factors have been associated with regulating the differentiation of oligodendroglia and myelination, glutamate signalling might be particularly important for learning-dependent myelination. The majority of myelinated projection neurons are glutamatergic. Oligodendrocyte precursor cells receive glutamatergic synaptic inputs from unmyelinated axons and oligodendrocyte lineage cells express glutamate receptors which enable them to monitor and respond to changes in neuronal activity. Yet, what role glutamate plays for oligodendroglia is not fully understood. Here, we review glutamate signalling and its effects on oligodendrocyte lineage cells, and myelination in health and disease. Furthermore, we discuss whether glutamate signalling between neurons and oligodendroglia might lay the foundation to activity-dependent white matter plasticity. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

References

Jan 1, 1991·Annual Review of Biochemistry·H R Herschman
Jan 1, 1970·European Journal of Pharmacology·B ScattonJ Glowinski
Nov 1, 1981·Brain Research Bulletin·H M DuvernoyJ L Vannson
Nov 1, 1996·The European Journal of Neuroscience·J M García-Barcina, C Matute
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·C MatuteR Miledi
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Jun 26, 1999·The European Journal of Neuroscience·M DomercqC Matute
Dec 29, 1999·Nature Medicine·D PittC S Raine
Sep 23, 2000·Brain Research. Molecular Brain Research·D J FogartyC Matute
Dec 15, 2000·Plant Physiology·K L Dennison, E P Spalding
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W RzeskiC Ikonomidou
May 23, 2001·Progress in Neurobiology·N C Danbolt
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P G Genever, T M Skerry
Jan 5, 2002·Current Opinion in Pharmacology·A L Kirchgessner
Apr 19, 2002·Journal of Neuroimmunology·Makoto OhgohYukio Nishizawa
Jun 26, 2002·Molecular Biology and Evolution·Joanna C ChiuGloria M Coruzzi
Sep 5, 2002·Nature Reviews. Neuroscience·Robin J M Franklin
Dec 28, 2002·Journal of Neuroscience Research·Paul A RosenbergJoseph J Volpe
Feb 1, 2003·Journal of the Neurological Sciences·C BjartmarB D Trapp
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Mark P Goldberg, Bruce R Ransom
Apr 22, 2004·Nature Reviews. Neuroscience·Noam E Ziv, Craig C Garner
Jun 9, 2004·The Journal of Biological Chemistry·Rodrigo PachecoRafael Franco
Sep 1, 2004·Pflügers Archiv : European journal of physiology·Nicola J AllenDavid Attwell
Oct 7, 2004·Biochemical and Biophysical Research Communications·Alexander A BoldyrevDavid O Carpenter

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Citations

Oct 25, 2016·Trends in Pharmacological Sciences·Amit MoghaKelly R Monk
Oct 30, 2016·Neuropharmacology·Jeffrey K Huang, Ragnhildur T Káradóttir
Jan 27, 2017·International Journal of Molecular Sciences·Zhe ZhangHui Jiang
May 10, 2018·Brain Pathology·Alexander SosunovJames E Goldman
Dec 29, 2017·Journal of Lipid Research·Sergei A NovgorodovTatyana I Gudz
Apr 6, 2018·Annual Review of Neuroscience·Ragnhildur T Káradóttir, Chay T Kuo
Sep 19, 2018·Journal of Neurochemistry·Omar de FariaJunhua Xiao
Mar 14, 2018·Nature Communications·Sean DoyleRobert Fern
Apr 9, 2019·Glia·Chloé HabermacherNajate Benamer
Sep 25, 2017·Developmental Neurobiology·Omar de FariaRagnhildur Thóra Káradóttir
Nov 5, 2019·The International Journal of Neuroscience·Yuhua ZhanXumei Wang
Dec 12, 2017·Autism Research : Official Journal of the International Society for Autism Research·Audrey ThurmLonnie Zwaigenbaum
Jan 11, 2019·Neurochemical Research·Edna Suárez-PozosBabette Fuss
Jan 31, 2020·Neurochemical Research·Maryna BaydyukJeffrey K Huang
Apr 27, 2017·Neurochemical Research·Robert Fern
Nov 13, 2018·Frontiers in Neuroscience·Alexander A IlyasovAllyn C Howlett
Oct 2, 2019·Neural Regeneration Research·Ting-Jiun Chen, Maria Kukley
Dec 7, 2018·Frontiers in Cellular Neuroscience·Zahraa ChorghayEdward S Ruthazer
Oct 31, 2018·Frontiers in Cellular Neuroscience·Rafael Góis Almeida
Jul 1, 2020·Frontiers in Cellular Neuroscience·Giulia BonettoRagnhildur Thóra Káradóttir
Mar 16, 2021·Frontiers in Veterinary Science·Toni SchumacherSteffen Maak
Jul 25, 2021·International Journal of Molecular Sciences·Federica CherchiElisabetta Coppi
Dec 10, 2020·Seminars in Cell & Developmental Biology·Michelle Monje, Ragnhildur Thóra Káradóttir
Jul 4, 2021·British Journal of Pharmacology·Tania AguadoJavier Palazuelos

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