Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors

Hippocampus
C Schwarzer, G Sperk

Abstract

The influence of intrahippocampal injections of glutamate receptor agonists on neuropeptide Y (NPY) mRNA expression was investigated in granule cells and interneurons of the rat dentate gyrus. One day after local injection of non-neurodegenerative doses (20 and 70 nmol) of the metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate [(1S,3R)ACPD], NPY mRNA levels were more than doubled in ipsilateral granule cells and interneurons. Doses of 200 and 400 nmol caused up to 15.9- and 4.6-fold mRNA increases in granule cells and interneurons, respectively. The group I metabotropic glutamate receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG; 50 nmol), but not the group III receptor agonist L(+)-2-amino-4-phosphonobutyrate (L-AP4; 20 and 200 nmol) exerted a similar action. The general metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine (MCPG; 200 nmol), the group I receptor antagonist (S)-4-carboxyphenylglycine (4-CPG; 200 nmol) and the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (1 mg/kg; i.p.) partially blocked the (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate-induced increase in NPY mRNA in granule cells, but not in interneurons. (S)-4-carboxyphenylglycine ...Continue Reading

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Citations

Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonio P SilvaEric Grouzmann
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini
Jul 19, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brian A BaldoRuth M Benca
Nov 30, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria SmiałowskaBarbara Zieba
May 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Su GaoGary D Lopaschuk
Mar 11, 2004·Journal of Neurochemistry·Pascal E D Lachance, Avi Chaudhuri
Dec 30, 2008·Pharmacological Reviews·Francesco FerragutiFerdinando Nicoletti
Aug 22, 2017·Frontiers in Molecular Neuroscience·Johannes Burtscher, Christoph Schwarzer

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