Glutamate-stimulated production of inositol phosphates is mediated by Ca2+ influx in oligodendrocyte progenitors

European Journal of Pharmacology
H N LiuG Almazan

Abstract

The effect of glutamate on the accumulation of [3H]inositol phosphates was examined in oligodendrocyte progenitor cultures prepared from rat brains. Glutamate, and the analogues alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate, caused a concentration- and time-dependent increase in [3H]inositol trisphosphate (IP3) formation and the effect was blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a competitive AMPA and kainate receptor antagonist. Similarly, the more selective, noncompetitive antagonist of AMPA receptors, 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466), significantly reduced the effect of both AMPA and kainate. In contrast, antagonists of N-methyl-D-aspartate (NMDA) receptor, (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5, 10-imine (MK-801) and R(-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), and antagonists of metabotropic receptors, L(+)-2-amino-3-phosphono-propanoic acid (L-AP3) and alpha-methyl-4-carboxyphenylglycine (MCPG), were ineffective. These results suggest that the effect of glutamate on [3H]IP3 accumulation is mediated through ionotropic AMPA receptors. Cyclothiazide, an inhibitor of AMPA receptor desens...Continue Reading

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Citations

Jan 13, 2000·Neuropathology and Applied Neurobiology·J E Merrill, N J Scolding
May 4, 2011·Journal of Neurotrauma·Julieann C Durham-LeeOlivera Nesic
Jun 30, 2001·Japanese Journal of Pharmacology·N KönigJ M Exbrayat
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Aug 13, 2005·Cell Calcium·Elena AlberdiCarlos Matute
Jan 15, 2014·Neuropharmacology·Shireen HossainGuillermina Almazan
Oct 25, 2006·Journal of Neurochemistry·Ragunathan Padmashri, Sujit Kumar Sikdar
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Feb 24, 2018·Journal of Neurochemistry·Jens IngwersenTim Prozorovski
May 23, 2000·Journal of Neurochemistry·Y H LeeW Tsai

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