Glutamate transmission rather than cellular pacemaking propels excitatory-inhibitory resonance for ictogenesis in amygdala.

Neurobiology of Disease
Guan-Hsun WangChung-Chin Kuo

Abstract

Epileptic seizures are automatic, excessive, and synchronized neuronal activities originating from many brain regions especially the amygdala, the allocortices and neocortices. This may reflect a shared principle for network organization and signaling in these telencephalic structures. In theory, the automaticity of epileptic discharges may stem from spontaneously active "oscillator" neurons equipped with intrinsic pacemaking conductances, or from a group of synaptically-connected collaborating "resonator" neurons. In the basolateral amygdalar (BLA) network of pyramidal-inhibitory (PN-IN) neuronal resonators, we demonstrated that rhythmogenic currents are provided by glutamatergic rather than the classic intrinsic or cellular pacemaking conductances (namely the h currents). The excitatory output of glutamatergic neurons such as PNs presumably propels a novel network-based "relay burst mode" of discharges especially in INs, which precondition PNs into a state prone to burst discharges and thus further glutamate release. Also, selective activation of unilateral PNs, but never INs, readily drives bilateral BLA networks into reverberating discharges which are fully synchronized with the behavioral manifestations of seizures (e.g. m...Continue Reading

References

Sep 1, 1990·Annals of Neurology·M R Sperling, M J O'Connor
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Dec 10, 1982·The Journal of Comparative Neurology·A J McDonald
Apr 1, 1993·Journal of Neurophysiology·D G RainnieP Shinnick-Gallagher
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
May 13, 1998·Epilepsia·E PeruccaO Dulac
Jul 13, 1999·Journal of Neurophysiology·D G Rainnie
Mar 21, 2000·Brain & Development·P Genton
Feb 22, 2001·Annual Review of Physiology·D A McCormick, D Contreras
May 4, 2002·Nature Reviews. Neuroscience·Vincenzo Crunelli, Nathalie Leresche
Jul 5, 2003·Physiological Reviews·P SahJ Power
Jul 10, 2003·Current Opinion in Neurobiology·Alan L Goldin
Mar 1, 1956·A.M.A. Archives of Neurology and Psychiatry·J D FRENCHR B LIVINGSTON
Dec 9, 2003·Nature Reviews. Neuroscience·Rüdiger Krahe, Fabrizio Gabbiani
Jun 15, 2004·Progress in Neurobiology·Kiyoshi MorimotoRonald J Racine
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Volodymyr I Dzhala, Kevin J Staley
Apr 29, 2005·Epilepsia·James X TaoJohn S Ebersole
Sep 28, 2005·Progress in Brain Research·Hal Blumenfeld
Jan 3, 2006·Neuron·Liset Menendez de la PridaRichard Miles
Apr 13, 2006·Developmental Medicine and Child Neurology·N A Gayatri, J H Livingston
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alan R Woodruff, Pankaj Sah
Jun 16, 2007·Epilepsia·Edward Bertram
May 28, 2008·Epilepsia·Dan C McIntyre, Krista L Gilby
May 28, 2008·Epilepsia·Andro ZangaladzeMichael R Sperling
Dec 6, 2008·Epilepsia·Jerome EngelIstvan Mody
Mar 21, 2009·Science·Viviana GradinaruKarl Deisseroth
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ethan G HughesRita J Balice-Gordon
May 21, 2010·Journal of Neurophysiology·Ludmila SosulinaHans-Christian Pape
Nov 26, 2010·Neuropharmacology·Jay SpampanatoPankaj Sah
Dec 18, 2010·Lancet Neurology·Josep DalmauRita Balice-Gordon
Dec 28, 2010·Biochemical and Biophysical Research Communications·Kyungjoon ParkKi Soon Shin
Jul 26, 2011·Current Opinion in Neurobiology·Yoav NoamTallie Z Baram
Jan 24, 2013·Nature Communications·Esther Krook-MagnusonIvan Soltesz
Apr 18, 2013·PloS One·Shin-Ichiro OsawaHajime Mushiake

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Citations

Mar 22, 2021·Annals of Neurology·Yun-Chu LinChung-Chin Kuo
Aug 20, 2021·Frontiers in Systems Neuroscience·Ping Chou, Chung-Chin Kuo

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