Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices

Brain Research
Gabriella NyitraiJulianna Kardos

Abstract

A wide range of data support a role for ambient glutamate (Glu) in epilepsy, although temporal patterns associated with the cellular uptake of Glu have not been addressed in detail. We report on the effects of Glu uptake inhibitors on recurrent seizure-like events (SLEs) evoked by low-[Mg(2+)] condition in juvenile rat hippocampal slices. Effects were compared for inhibitors such as L-trans-pyrrolidine-2,4-dicarboxylate (tPDC), DL-threo-beta-benzyloxyaspartate (DL-TBOA) and dihydrokainic acid (DHK), representing different transporter specificity and transportability profiles. Latency to the first SLE after drug application was shortened by the inhibitors (in % of control: 500 microM tPDC: 54+/-7, 15 microM DL-TBOA: 74+/-5, 50 microM dl-TBOA: 70+/-6, 100 microM DHK: 69+/-4, 300 microM DHK: 71+/-7). Further SLEs were frequently aborted by higher inhibitor concentrations applied (500 microM tPDC: 2/6, 50 microM TBOA: 5/5, 100 microM DHK: 6/8, 300 microM DHK: 3/3). Simultaneous field potential and whole-cell voltage recordings showed depolarization-induced inactivation of CA3 pyramidal neurons during inhibitor application. In the presence of inhibitors, the amplitude of forthcoming SLE was also decreased (in % of control: 500 micro...Continue Reading

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Citations

Mar 17, 2012·BMC Biology·László HéjaJulianna Kardos
Jun 22, 2011·Nanotoxicology·Gabriella NyitraiJulianna Kardos
Sep 20, 2011·Experimental Neurology·Gerald Seifert, Christian Steinhäuser
Nov 1, 2015·Bulletin of Experimental Biology and Medicine·V G Motin, V V Yasnetsov

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