Glutamatergic Biomarkers for Cocaine Addiction: A Longitudinal Study Using MR Spectroscopy and mGluR5 PET in Self-Administering Rats

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Bart de LaatKoen Van Laere

Abstract

Cocaine addiction is a disorder that still lacks diagnostic biomarkers or effective pharmacotherapy. We present findings on a rat model of cocaine self-administration that was followed up longitudinally using the metabotropic glutamate receptor type 5 (mGluR5) tracer 18F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile (18F-FPEB) PET, proton MR spectroscopy (1H-MRS), and behavioral tests. Methods: Forty-two Wistar rats were scanned with 18F-FPEB PET and 1H-MRS before and after sucrose or intravenous cocaine self-administration, during withdrawal, and during relapse. All animals performed a rodent Iowa Gambling Task (rIGT) at baseline to evaluate decision making. Baseline values were used in a mixed model to assess associations with later cocaine use, and follow-up measurements were compared with the values before drug exposure. Results: Preexposure rIGT scores were significantly related to both cocaine and sucrose use during the drug-exposure phase. However, only cocaine self-administration induced a decrease in 18F-FPEB binding. This decrease was most pronounced bilaterally in the hippocampus, where mGluR5 availability correlated with the amount of cocaine used during relapse. Compared with the sucrose group, a larger decrease w...Continue Reading

References

Jul 23, 1999·Annals of the New York Academy of Sciences·B J EverittT W Robbins
Jan 24, 2009·Current Opinion in Pharmacology·Kent C BerridgeJ Wayne Aldridge
Jun 19, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fiona D ZeebCatharine A Winstanley
Jun 24, 2009·The International Journal of Neuropsychopharmacology·Michael K BirdAndrew J Lawrence
Jul 3, 2009·Nature Reviews. Neuroscience·Peter W Kalivas
Jan 26, 2010·Psychiatry Research·Jaromir HonsJan Libiger
Mar 6, 2010·Annals of the New York Academy of Sciences·Heath D Schmidt, R Christopher Pierce
Sep 26, 2012·Nature Neuroscience·Ralph J DiLeoneMarina R Picciotto
Jan 22, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bill P GodsilThérèse M Jay
Sep 3, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aram Parsegian, Ronald E See
Nov 28, 2013·Pharmaceuticals·Seven E TomekM Foster Olive
Oct 14, 2014·Current Psychiatry Reports·Kathleen A Garrison, Marc N Potenza
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Joseph O'NeillEdythe D London
Sep 26, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bart de LaatCindy Casteels
Nov 19, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Soyka, Jochen Mutschler
Jul 13, 2016·Biological Psychiatry·Kelly P Cosgrove
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow

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Citations

Apr 15, 2020·Scientific Reports·Yoan MihovGregor Hasler
May 16, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sylvia M L CoxMarco Leyton
Dec 29, 2020·Pharmacology & Therapeutics·Ewa Niedzielska-AndresEdmund Przegaliński
Jan 10, 2021·Journal of Neurochemistry·Rusty W NallAna-Clara Bobadilla
Aug 31, 2020·Current Opinion in Behavioral Sciences·Cole Vonder Haar
Sep 5, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jenny CeccariniKoen Van Laere

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