Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension.

The Journal of Physiology
Tyler BastingEric Lazartigues

Abstract

Recurrent periods of over-excitation in the paraventricular nucleus (PVN) of the hypothalamus could contribute to chronic over-activation of this nucleus and thus enhanced sympathetic drive. Stimulation of the PVN glutamatergic population utilizing channelrhodopsin-2 leads to an immediate frequency-dependent increase in baseline blood pressure. Partial lesions of glutamatergic neurons of the PVN (39.3%) result in an attenuated rise in blood pressure following Deoxycorticosterone acetate (DOCA)-salt treatment and reduced index of sympathetic activity. These data suggest that stimulation of PVN glutamatergic neurons is sufficient to cause autonomic dysfunction and drive the increase in blood pressure during hypertension. Neuro-cardiovascular dysregulation leads to increased sympathetic activity and neurogenic hypertension. The paraventricular nucleus (PVN) of the hypothalamus is a key hub for blood pressure (BP) control, producing or relaying the increased sympathetic tone in hypertension. We hypothesize that increased central sympathetic drive is caused by chronic over-excitation of glutamatergic PVN neurons. We tested how stimulation or lesioning of excitatory PVN neurons in conscious mice affects BP, baroreflex and sympathetic...Continue Reading

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Citations

Oct 1, 2019·Hypertension·Snigdha MukerjeeEric Lazartigues
Jan 12, 2020·Current Hypertension Reports·Pablo NakagawaCurt D Sigmund
Oct 6, 2020·Clinical Science·Mazher MohammedEric Lazartigues
Jan 9, 2021·Clinical Science·Mona Elgazzaz, Eric Lazartigues
Dec 31, 2020·International Journal of Molecular Sciences·Rohan Umesh Parekh, Srinivas Sriramula
Mar 18, 2021·Cell Reports·David I LeviCharles W Bourque
Dec 16, 2021·Cellular and Molecular Life Sciences : CMLS·Anup BhusalKyoungho Suk

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