Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Anant B PatelKevin L Behar

Abstract

13C nuclear magnetic resonance (NMR) experiments have previously shown that glutamatergic neurotransmitter flux (Vcycle(Glu/Gln)) changes proportionately with neuronal glucose oxidation (CMRglc(ox)N) in the nonactivated cortex of anesthetized rats. Positron Emission Tomography measurements of glucose and oxygen uptake during sensory stimulation had shown that the incremental glucose utilization is greater than oxygen leading to the suggestion that the energy required for stimulated neuronal activity arises from nonoxidative glucose metabolism. In this study, the authors used spatially localized 1H-observed, 13C-edited NMR spectroscopy during an infusion of [1,6-13C2]glucose to assess the relationship between changes in Vcycle(Glu/Gln) and glucose utilization (CMRglc(ox)N and CMRglc(nonox)) during the intense cortical activity associated with bicuculline-induced seizures. Metabolic fluxes were determined by model-based analysis of the 13C-enrichment time courses of glutamate-C4 and glutamine-C4 (CMRglc(ox)N, Vcycle(Glu/Gln)) and lactate-C3 (CMRglc(nonox)). The exchange rate between alpha-ketoglutarate and glutamate was found to be significantly faster than TCA cycle flux both for control (41 micromol.g(-1).min(-1); 95% CI, 5 to ...Continue Reading

References

May 1, 1977·Journal of Neurochemistry·A G ChapmanB K Siesjö
May 1, 1977·The Journal of General Physiology·F Proverbio, J F Hoffman
Dec 1, 1978·Brain : a Journal of Neurology·G BlennowB K Siesjö
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G F MasonR G Shulman
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S M FitzpatrickR G Shulman
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B KalderonA Lapidot
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G BlennowB K Siesjö
Nov 1, 1973·Journal of Neurochemistry·U PonténB K Siesjö
Aug 17, 1984·Biochimica Et Biophysica Acta·R S Balaban, J P Bader
Oct 1, 1983·Physiological Reviews·W M Pardridge
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G F MasonE J Novotny
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N R SibsonR G Shulman
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·N R SibsonR G Shulman
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·R G Shulman, D L Rothman
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A de Graaf, K Nicolay
Feb 13, 1999·Science·P J MagistrettiR G Shulman
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ShenD L Rothman
Nov 18, 2000·American Journal of Physiology. Cell Physiology·J L GriffinE D Lewandowski
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N CholetG Bonvento
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanD L Rothman
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·R GruetterK Ugurbil
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Dec 18, 2001·Journal of Neuroscience Research·G A Dienel, L Hertz
Jul 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Arien J SmithFahmeed Hyder
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·In-Young ChoiRolf Gruetter
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin A de GraafKevin L Behar

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Citations

Mar 27, 2007·Annals of Biomedical Engineering·R OcchipintiD Calvetti
Apr 11, 2012·Neurochemical Research·Tore EidTih-Shih W Lee
Jun 4, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Thomas Ernst, Linda Chang
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anant B PatelKevin L Behar
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert G ShulmanDouglas L Rothman
Dec 8, 2007·Cerebral Cortex·Ulrich SchriddeHal Blumenfeld
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Alexander A ShestovGülin Öz
Oct 30, 2012·Neurochemical Research·Douglas L RothmanKevin L Behar
Mar 4, 2014·Magnetic Resonance Imaging·Daniel ComanFahmeed Hyder
Dec 3, 2015·Neurochemistry International·Puneet BaggaAnant B Patel
Nov 24, 2011·Neurochemistry International·Puneet Bagga, Anant Bahadur Patel
Oct 19, 2010·Medical Hypotheses·Edward Henry MathewsRuaan Pelzer
Jan 22, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jehoon YangJun Shen
May 9, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F Mark JeffreyCraig R Malloy
Oct 18, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sébastien SerresMichel Merle
Jul 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ai-Ling LinFahmeed Hyder
Sep 4, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jun ShenSu Xu
Nov 17, 2007·Neurochemistry International·Paul K Maciejewski, Douglas L Rothman
May 7, 2009·Journal of Neurochemistry·Dinesh K DeelchandPierre-Gilles Henry
Oct 13, 2006·Journal of Neurochemistry·Carole EscartinGilles Bonvento
Sep 2, 2011·NMR in Biomedicine·Douglas L RothmanKevin L Behar
Sep 16, 2011·NMR in Biomedicine·Robin A de GraafKevin L Behar
Nov 3, 2010·Journal of Neurochemistry·Anne B WallsHelle S Waagepetersen
Dec 17, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Min-Su LeeKi-Dong Eom
Apr 12, 2015·Cell Metabolism·Liming PeiRonald M Evans
Sep 29, 2011·Journal of Neuroscience Methods·Isaac Marin-ValenciaJuan M Pascual
Apr 11, 2009·Neuroscience·J B Savitz, W C Drevets
Jan 20, 2007·NeuroImage·Roberto C Sotero, Nelson J Trujillo-Barreto
Feb 5, 2015·BioMed Research International·Sreekanth PuttacharyThimmasettappa Thippeswamy
Aug 16, 2016·Analytical Biochemistry·Julien ValetteFawzi Boumezbeur
Jun 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anant B PatelKamal Saba
Jan 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fahmeed HyderRobert G Shulman
Jul 31, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Puneet BaggaAnant B Patel
Feb 10, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lasse K BakHelle S Waagepetersen

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Methods Mentioned

BETA
NMR
nuclear magnetic resonance

Software Mentioned

LabView
CWave
SWAMP
SAS

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