Glutamatergic-receptors blockade does not regularize the slow wave sleep bursty pattern of subthalamic neurons

The European Journal of Neuroscience
N UrbainG Chouvet

Abstract

The subthalamic nucleus (STN) has been implicated in movement disorders observed in Parkinson's disease because of its pathological mixed burst firing mode and hyperactivity. In physiological conditions, STN bursty pattern has been shown to be dependent on slow wave cortical activity. Indeed, cortical ablation abolished STN bursting activity in urethane-anaesthetized intact or dopamine depleted rats. Thus, glutamate afferents might be involved in STN bursting activity during slow wave sleep (SWS) when thalamic and cortical cells oscillate in a low-frequency range. The present work was aimed to test, on non-anaesthetized rats, if it was possible to regularize the SWS STN bursty pattern by microiontophoresis of kynurenate, a broad-spectrum glutamate ionotropic receptors antagonist. As glutamatergic effects might be masked by GABAergic inputs arriving tonically and during the entire sleep-wake cycle on STN neurons, kynurenate was also co-iontophoresed with bicuculline, a GABA(A) receptors antagonist. Kynurenate iontophoretic applications had a weak inhibitory effect on the discharge rate of STN neurons whatever the vigilance state, and did not regularize the SWS STN bursty pattern. But, the robust bursty bicuculline-induced patter...Continue Reading

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Citations

Dec 6, 2005·Experimental Brain Research·Alessandro StefaniPaolo Mazzone
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lionel DahanGuy Chouvet
Nov 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J BaufretonA I Taupignon
Apr 15, 2006·The Journal of Physiology·Nadia UrbainGuy Debonnel

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