Glutamatergic Transmission: A Matter of Three

Neural Plasticity
Zila Martínez-Lozada, Arturo Ortega

Abstract

Glutamatergic transmission in the vertebrate brain requires the involvement of glia cells, in a continuous molecular dialogue. Glial glutamate receptors and transporters are key molecules that sense synaptic activity and by these means modify their physiology in the short and long term. Posttranslational modifications that regulate protein-protein interactions and modulate transmitter removal are triggered in glial cells by neuronal released glutamate. Moreover, glutamate signaling cascades in these cells are linked to transcriptional and translational control and are critically involved in the control of the so-called glutamate/glutamine shuttle and by these means in glutamatergic neurotransmission. In this contribution, we summarize our current understanding of the biochemical consequences of glutamate synaptic activity in their surrounding partners and dissect the molecular mechanisms that allow neurons to take control of glia physiology to ensure proper glutamate-mediated neuronal communication.

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Citations

May 18, 2016·Neurochemistry International·Orquidia G Mendez-FloresArturo Ortega
Feb 8, 2018·Pharmaceuticals·José J Jarero-BasultoCarlos Beas-Zarate
Sep 7, 2017·Molecular Neurobiology·Reynaldo Tiburcio-FélixArturo Ortega
Sep 6, 2017·Archiv der Pharmazie·Daniela R OliveiraJoão P S Fernandes
Jul 12, 2019·Neurotoxicity Research·Ada G Rodríguez-CampuzanoArturo Ortega
Feb 28, 2018·Frontiers in Physiology·Donají Chi-Castañeda, Arturo Ortega
Aug 1, 2019·Neurochemical Research·Miguel EscalanteArturo Ortega
Jan 11, 2019·Neurochemical Research·Edna Suárez-PozosBabette Fuss
Aug 1, 2020·Neurotoxicity Research·Ana L García-LópezArturo Ortega
Jan 26, 2021·Frontiers in Neuroscience·Catya Jiménez-TorresMustapha Najimi
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Zefeng ChenGuobin Wu
Jun 3, 2021·International Journal of Molecular Sciences·Chia-Yuan ChangWen-Sung Lai
May 16, 2019·ACS Chemical Neuroscience·Reynaldo Tiburcio-FélixArturo Ortega

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Methods Mentioned

BETA
fluorescence microscopy

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