Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast

Neurology India
Pankaj A Agarwal, Nasli R Ichaporia

Abstract

Stiff limb syndrome (SLS) is a rare "focal" variant of stiff person syndrome which presents with rigidity and painful spasms of a distal limb, and abnormal fixed foot or hand postures. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) are variably present in most cases. Most reported cases of SLS are unassociated with cancer. We describe a patient with SLS as a paraneoplastic manifestation of breast carcinoma, in whom GAD-Ab was present. The patient responded very well to oral diazepam, baclofen and steroids.This is the third reported case of SLS as a paraneoplastic accompaniment to cancer.

References

Jan 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·P BrownC D Marsden
Mar 20, 1998·Annals of Neurology·A SaizE Tolosa
Aug 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·I E Silverman
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·C F Souza-LimaG M Manzano
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A Coles, R Barker
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·M E GürolM Emre
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Hans-Michael Meinck, Philip D Thompson
May 23, 2003·Journal of Neurology·T BartschG Deuschl

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Citations

Feb 8, 2011·Journal of Neurology·C VenkerP Berlit
Sep 23, 2011·Acta Neuropathologica·Andrew McKeon, Sean J Pittock
Aug 12, 2014·Survey of Ophthalmology·Ying ChenJason J S Barton
Sep 14, 2016·Analytica Chimica Acta·Adenilton C da SilvaMário César U de Araújo
Nov 2, 2016·Experimental Hematology & Oncology·Ibrahim Fanous, Patrick Dillon

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