Glutamic acid induces luteinizing hormone releasing hormone release via alpha receptors

Brain Research Bulletin
A KamatS M McCann

Abstract

Glutamic acid (GA) and norepinephrine (NE) stimulate luteinizing hormone-releasing hormone (LHRH) release via release of nitric oxide (NO) from NOergic neurons in the arcuate-median eminence region. To determine if GA releases LHRH via direct stimulation of NOergic neurons, or via stimulation of noradrenergic terminals, arcuate median eminence explants from male rats were incubated with various compounds, and the LHRH release into the medium was measured. GA-induced release of LHRH was completely blocked by phentolamine (1 microM), an alpha receptor blocker, which, by itself, had no effect on the release. Nitroprusside (NP), which spontaneously releases NO, more than doubled LHRH release. To determine if alpha receptors on the LHRH neuron are required for the action of NP, the tissue was incubated with phentolamine, plus NP. Phentolamine had no effect on the LHRH-releasing action of NP. The results are interpreted to mean that GA activates the release of NE from the noradrenergic terminals. This acts on alpha receptors on the NOergic neuron to produce the release of NO. This NO diffuses to the LHRH terminals and induces release of LHRH.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
May 1, 1992·Trends in Endocrinology and Metabolism : TEM·D W Brann, V B Mahesh

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Citations

Jan 16, 2014·Indian Journal of Clinical Biochemistry : IJCB·Emad F EskanderHanaa H Ahmed
Aug 5, 2005·Steroids·Darrell W Brann, Virendra B Mahesh
Jul 1, 1997·Experimental Gerontology·S M McCann
Feb 10, 1999·Experimental Gerontology·S M McCannV Rettorri
Oct 24, 1998·Domestic Animal Endocrinology·S M McCannW H Yu
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SeilicovichS M McCann
Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margarita C Currás-Collazo
Jul 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Juan Pablo PrestifilippoValeria Rettori
Jun 18, 1998·Annals of the New York Academy of Sciences·S M McCannV Rettori
Jun 18, 1998·Annals of the New York Academy of Sciences·V Rettori, S M McCann
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A G FalettiV Rettori
Feb 25, 2009·Annals of the New York Academy of Sciences·Valeria RettoriAndrea De Laurentiis
Nov 14, 1997·Frontiers in Neuroendocrinology·R J NelsonT M Dawson
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M McCannW H Yu
Mar 28, 2001·Annals of the New York Academy of Sciences·S M McCannV Rettori

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