PMID: 6126832May 1, 1982Paper

Glutamine and alpha-ketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum

Neurochemical Research
R P Shank, G L Campbell

Abstract

In order to provide evidence relevant to the hypothesis that nonsynaptically derived alpha-ketoglutarate serves as a metabolic precursor of the neurotransmitter pools of glutamate and GABA the uptake and metabolism of alpha-ketoglutarate by nerve terminal enriched material was studied and compared to corresponding data for glutamine. Both alpha-ketoglutarate and glutamine were transported across the cell membrane by high affinity and low affinity carriers. Under conditions prevailing in vivo alpha-ketoglutarate probably is transported primarily by its high affinity carrier, whereas gluatmine should be transported primarily by one or more low affinity carriers. Based upon reciprocal uptake inhibition experiments glutamine appeared to be transported by the alanine preferring system, and to a lesser extent by the basic amino acid and large neutral amino acid carriers. A comparison of the rate of uptake by different cellular preparations enriched in either nerve terminals or cell bodies indicated that alpha-ketoglutarate is transported selectively by nerve terminals. Both substrates were rapidly converted to glutamate; however, glutamine was more readily metabolized to GABA. The results of our study are consistent with the concept ...Continue Reading

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Citations

Nov 25, 2004·Journal of Neuroscience Research·Anant B PatelKevin L Behar
Aug 1, 1993·Journal of Neuroscience Research·N WestergaardA Schousboe
May 1, 1993·The Histochemical Journal·P Kugler
Mar 1, 1992·Metabolic Brain Disease·V L RaoR F Butterworth
Feb 23, 1981·Life Sciences·R P Shank, M H Aprison
Jan 1, 1993·Progress in Biophysics and Molecular Biology·F Fonnum
Jan 1, 1990·Progress in Neurobiology·M Erecińska, I A Silver
Oct 26, 1999·Progress in Retinal and Eye Research·M Kalloniatis, G Tomisich
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E M WrightI Kippen
Jun 1, 1990·Journal of Neurochemistry·M ErecińskaM Yudkoff
Jul 1, 1991·Journal of Neurochemistry·M YudkoffM Erecińska
Oct 30, 2012·Neurochemical Research·Douglas L RothmanKevin L Behar
Dec 1, 1990·Neurochemical Research·M C McKennaF J Caprio
May 28, 2015·Neurochemical Research·John T Hackett, Tetsufumi Ueda
Nov 17, 2007·Neurochemistry International·Paul K Maciejewski, Douglas L Rothman
Dec 31, 1992·Behavioural Brain Research·R Kötter, N Meyer
Aug 1, 1989·Journal of Neurochemistry·M YudkoffM Erecińska
Nov 1, 1984·Journal of Neurochemistry·J D Rothstein, B Tabakoff
Feb 1, 1987·Journal of Neurochemistry·R J WentholdK A Reeks
Aug 1, 1987·Journal of Neurochemistry·R P ShankJ J Tighe
Nov 1, 1983·Journal of Neurochemistry·A C YuA Schousboe
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Apr 1, 1984·Journal of Neurochemistry·J L Johnson, E Roberts
Oct 1, 1988·Journal of Neurochemistry·R E PaulsenF Fonnum
Jan 1, 2014·International Scholarly Research Notices·Ravi Kant Upadhyay

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