PMID: 9527969Apr 7, 1998Paper

Glutamine and nucleotide metabolism within enterocytes

JPEN. Journal of Parenteral and Enteral Nutrition
R McCauleyJ Hall

Abstract

Glutamine has an important role as a source of energy for enterocytes. However, it may also have a key role as a source of nitrogen for the synthesis of nucleotides. The relative contribution of de novo synthesis and salvage pathways seems to be affected by the position of enterocytes within the crypt-villus axis as well as the dietary intake of nucleic acids and glutamine. Nucleotides are especially important to enterocytes during intestinal development, maturation, and repair. Hence an understanding of nucleotide metabolism within enterocytes has important implications regarding both the composition and route of administration of nutrient solutions. Many important questions remain unanswered, in particular: Does glutamine stimulate intestinal de novo pyrimidine synthesis via the action of carbamoyl phosphate synthetase I? Can de novo purine synthesis maintain intestinal purine pools in the absence of dietary nucleic acids? And, what are the specific effects of parenterally administered nucleotides on the metabolism and well-being of enterocytes? A greater understanding of these issues will lead to a more rational approach toward the nutritional modulation of gut dysfunction.

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Citations

Oct 25, 2000·The Journal of Nutritional Biochemistry·S E KongR D McCauley
Feb 19, 1999·Journal of the American College of Surgeons·P O Hasselgren
Mar 27, 2012·Journal of Clinical Biochemistry and Nutrition·Masaru OhtaniYasuyuki Okamoto
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Aug 19, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Mary E EvansThomas R Ziegler
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