PMID: 2119457Jul 1, 1990Paper

Glutamine-containing dipeptides in parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
P FürstP Stehle

Abstract

Of the total pool of muscle free intracellular amino acids, glutamine represents about 60%. During catabolic stress, a marked reduction (50%) of this pool occurs; the depletion is not reversible by therapeutic efforts or conventional nutritional means. If maintenance of the intracellular glutamine pool promotes conservation of muscle protein, there is a theoretical case for use of glutamine supplements in the parenteral nutrition of patients with injury and infection. Glutamine is too unstable and poorly soluble for addition to existing preparations in its native form, but this drawback can be overcome by the use of synthetic stable and highly soluble glutamine-containing dipeptides. In vivo studies in humans and animals provide firm evidence that a synthetic glutamine-containing dipeptide, L-alanyl-L-glutamine (Ala-Gln), is readily hydrolyzed following its intravenous administration. The results also indicate a safe and efficient use of Ala-Gln as a source of free glutamine in parenteral nutrition. In clinical studies, nitrogen balance was more positive in catabolic patients receiving a peptide-supplemented solution than in control patients given isonitrogenous, isoenergetic total parenteral nutrition. Muscle glutamine concent...Continue Reading

References

Oct 1, 1987·Metabolism: Clinical and Experimental·S A Adibi
Nov 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Stehle, P Fürst
Sep 12, 1988·FEBS Letters·P A MacLennanM J Rennie
Jan 1, 1985·Archives of Surgery·W W Souba, D W Wilmore
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·R J Valentine, W W Turner
May 1, 1985·Metabolism: Clinical and Experimental·W W SoubaD W Wilmore
Jun 1, 1974·Journal of Applied Physiology·J BergströmE Vinnars
Sep 1, 1983·The Proceedings of the Nutrition Society·P Fürst
Jan 1, 1956·Physiological Reviews·A MEISTER
Jan 1, 1932·The Biochemical Journal·A C Chibnall, R G Westall
Mar 1, 1982·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·E RothA Fritsch

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Citations

Dec 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G Wu, L W Greene
Mar 30, 2002·Advanced Drug Delivery Reviews·Eric Y ZhangPeter W Swaan
Apr 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·O E RooyackersA J Wagenmakers
Nov 20, 2003·Nutrition·Rosângela Passos de Jesus MazzaDan Linetzky Waitzberg
Jul 1, 1997·Nutrition·P FürstP Stehle
Aug 5, 1998·Alimentary Pharmacology & Therapeutics·A C StockdaleC R Pennington
Mar 1, 1997·The Proceedings of the Nutrition Society·C R Pennington
Aug 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus KratochwillChristoph Aufricht
Dec 1, 1993·Annals of Surgery·W W Souba
Jan 1, 1992·World Journal of Surgery·E E Tredget, Y M Yu
Dec 5, 2006·Seminars in Fetal & Neonatal Medicine·Prabhu S Parimi, Satish C Kalhan
Nov 3, 2006·Research in Veterinary Science·R JonassonM Jensen-Waern
Jan 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P Fürst
Jan 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H S Hundal
Feb 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P Fürst
Nov 1, 1994·Metabolism: Clinical and Experimental·A J KeeB Rowe
Jun 1, 1993·Journal of the American Dietetic Association·J D McCraeL M Udine
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·W K ChangM F Shaio
Mar 27, 2001·The Journal of Surgical Research·C T LiuC K Lii
Feb 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·V M Herrmann, P J Petruska
Jul 8, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·P Fürst
Mar 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·C K OgleJ W Alexander
Jun 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·P Fürst, P Stehle
Feb 22, 2011·Critical Care Medicine·Teodoro GrauUNKNOWN Metabolism, Nutrition Working Group, SEMICYUC, Spain
May 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Petra G BoelensNicolaas E Deutz
May 18, 2012·The Cochrane Database of Systematic Reviews·Ronald L KoretzTimothy O Lipman
Jan 17, 2014·Shock·Gisele Pena de OliveiraPatricia Rieken Macêdo Rocco
Jun 13, 1998·The Journal of Nutrition·P Fürst
Feb 1, 1995·The Annals of Pharmacotherapy·T W MattoxP G Cuddy

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