Glutamine-dependent changes in gene expression and protein activity

Cell Biochemistry and Function
Rui CuriTânia Cristina Pithon-Curi

Abstract

The functions of glutamine are many and include, substrate for protein synthesis, anabolic precursor for muscle growth, acid-base balance in the kidney, substrate for ureogenesis in the liver, substrate for hepatic and renal gluconeogenesis, an oxidative fuel for intestine and cells of the immune system, inter-organ nitrogen transport, precursor for neurotransmitter synthesis, precursor for nucleotide and nucleic acid synthesis and precursor for glutathione production. In the present review information on the mechanism of glutamine action is presented. This amino acid has been shown to regulate the expression of several genes (such as p47phox, p22phox, gp91phox, alpha-actin and fibronectin) and activate several proteins (such as ASK1, c-myc, c-jun and p70s6k).

References

Jan 1, 1990·Progress in Neurobiology·M Erecińska, I A Silver
Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·R J Smith, D W Wilmore
Feb 1, 1988·The Biochemical Journal·J M KowalchukE A Newsholme
Jul 16, 1986·Biochemical and Biophysical Research Communications·R CuriE A Newsholme
Jul 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·T HigashiguchiJ E Fischer
Jun 1, 1996·Current Opinion in Immunology·L Van Parijs, A K Abbas
Feb 25, 1998·Medicine and Science in Sports and Exercise·T E Graham, D A MacLean
Apr 29, 1998·Annual Review of Physiology·G KroemerM Resche-Rigon
Oct 22, 1998·Advances in Experimental Medicine and Biology·M J RennieA Ahmed
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R CuriA R Guimarães
Jul 20, 2000·European Journal of Nutrition·J J BozaO Ballèvre
May 18, 2001·Journal of Applied Physiology·P E WischmeyerE B Chang
May 30, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H M de SouzaR B Bazotte
Sep 5, 2001·The Journal of Nutrition·V R Young, A M Ajami
Feb 15, 2002·Nutrition·Shihab E O KhogaliMichael J Rennie
Mar 8, 2002·Nutrition·Erich RothAndreas Spittler
Mar 8, 2002·Nutrition·Paul E Wischmeyer
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·José M MatésJavier Márquez
Apr 30, 2002·Cell Biochemistry and Function·Tania C Pithon-CuriRui Curi
Apr 30, 2002·Cell Biochemistry and Function·Manuela M Ramos LimaRui Curi
Aug 3, 2002·European Journal of Biochemistry·Ulrike KrauseLouis Hue
Aug 8, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wei-Kuo ChangMen-Fang Shaio
Jan 17, 2003·American Journal of Physiology. Cell Physiology·Tania C Pithon-CuriRui Curi
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P NewsholmeR Curi
Feb 13, 2003·Cell Biochemistry and Function·Philip NewsholmeRui Curi

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Citations

Jun 18, 2009·Amino Acids·Tatiana Carolina Alba-LoureiroClaudia J Lagranha
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shawn D LarsonB Mark Evers
May 27, 2008·Journal of the International Society of Sports Nutrition·Lonnie Lowery, Cassandra E Forsythe
Jan 31, 2014·Cellular and Molecular Life Sciences : CMLS·S John CaliseEdward K L Chan
Jun 23, 2015·Journal of Gastroenterology and Hepatology·Raghupathy VenojiAnup Ramachandran
Aug 18, 2012·The Journal of Nutritional Biochemistry·Dominique Meynial-DenisJean-Pierre Renou
Apr 23, 2009·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yue-ping FanQun Zhang
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Paul E Wischmeyer
Oct 27, 2018·Nutrients·Vinicius CruzatPhilip Newsholme
Feb 26, 2020·Animals : an Open Access Journal From MDPI·Ali Mujtaba ShahJian Ma
Nov 9, 2020·Journal of Translational Medicine·Laura Di RenzoAntonino De Lorenzo
Jun 25, 2021·European Journal of Clinical Nutrition·Philip Newsholme
Jun 26, 2021·Nutrition & Diabetes·Philip Newsholme

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