Glutamine metabolism in Crohn's disease: a stable isotope study

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Arnaud BourreilleDominique Darmaun

Abstract

To determine whether chronic intestinal inflammation alters glutamine utilization, six 31 +/- 6 yr-old patients with Crohn's disease and an age-matched group of 6 healthy subjects received 7-h intravenous infusions of L-[5,5,5-2H3]leucine, along with an infusion of L-[1-13C]glutamine delivered intravenously for the first 3.5 h, and via a nasogastric tube for the subsequent 3.5 hrs. None of the patients was receiving any nutritional supplement or antiinflammatory drug. All were in remission (Crohn's disease activity index < 150) and in a near-normal nutritional status. We used plasma 2H3-alpha-ketoisocaproate to determine leucine appearance rate (Ra), and plasma 13C-glutamine and breath 13CO2 to determine glutamine Ra and oxidation, respectively. The fraction of enteral glutamine undergoing uptake in the splanchnic bed was determined from the difference in plasma 13C-glutamine enrichments between the intravenous and nasogastric 13C-glutamine infusion periods. Neither leucine Ra, nor plasma glutamine concentration (526 +/- 40 vs. 530 +/- 50 micromol/l), glutamine Ra (364 +/- 19 vs. 355 +/- 24 micromol kg(-1) h(-1)), or splanchnic glutamine uptake (61 +/- 5 vs. 65 +/- 2%) differed between groups. In both groups, glutamine oxidatio...Continue Reading

Citations

Jul 3, 2009·Inflammatory Bowel Diseases·Moïse CoëffierPierre Déchelotte
Feb 23, 2007·Pediatric Research·Tamara S HannonScott C Denne
May 21, 2016·Journal of Nutrition and Metabolism·Mechteld A R VermeulenPaul A M van Leeuwen
Sep 19, 2009·Nutrition Research·Andrea Ferreira S TannusJulio Sergio Marchini
Dec 29, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ronan ThibaultDominique Darmaun
Aug 2, 2008·The Journal of Physiology·Francesco AgostiniGianni Biolo
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Sep 23, 2008·The Journal of Nutrition·Robert F Bertolo, Douglas G Burrin
Jan 16, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Adam JirkaDominique Darmaun

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